Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years
Higher vitamin B12 levels in neurodevelopmental disorders than in healthy controls and schizophrenia A comparison among participants between 2 and 53 years
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DOI：
10.1096/fj.201900855rrr
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发表时间：
2020-04-22
期刊：
影响因子：
4.8
通讯作者：
Andreassen, Ole A.
中科院分区：
文献类型：
--
作者：
Hope, Sigrun;Naerland, Terje;Andreassen, Ole A.
最近的研究表明，高水平和低水平的维生素B12(VitB12)都可能对健康产生负面影响。我们测定了222例神经发育障碍(ND)患者(包括自闭症谱系障碍、特殊发育障碍和智能障碍(2-53岁))、精神分裂症(n=401)和健康对照(HC)(n=483)的VitB12。通过与参考人群(n=76 148)的比较，计算了年龄和性别调整后的vitB12 z得分。我们发现ND组的维生素B12(中位数420pmol/L，平均z分：0.3)高于HC组(316pmol/L，z分：0.06，P<0.01)和精神分裂症组(306pmol/L，z分：-0.02，P<0.01)，在调整了年龄、性别、补充维生素B12、叶酸、血红蛋白、白细胞、肝脏和肾功能后，差异有统计学意义(P<；02)。ND组中，20%(n=44)VitB12>650pmol/L，1%(n=3)VitB12低于150pmol/L(一般参考限值)。在6.3%(n=14)的ND中，经年龄和性别调整的参考人群中，vitB12的频率高于平均值的2SD，高于HC(n=8，1.6%)，OR：4.0，P=.001。VitB12低的发生率与HC相同，且各年龄组的VitB12 z得分相同。结论：ND组VitB12水平高于HC组和精神分裂症组，提示ND具有一定的特殊性，其发病机制值得进一步研究。
Recent studies suggest that both high and low levels of vitamin B12 (vitB12) may have negative health impacts. We measured VitB12 in patients with the Neurodevelopmental disorders (ND) (n = 222), comprised of Autism Spectrum Disorders, specific Developmental disorders, and Intellectual Disability (aged 2-53 years), schizophrenia (n = 401), and healthy controls (HC) (n = 483). Age-and gender-adjusted vitB12 z-scores were calculated by comparisons with a reference population (n = 76 148). We found higher vitB12 in ND (median 420 pmol/L, mean z-score: 0.30) than in HC (316 pmol/L, z-score: 0.06, P < .01) and schizophrenia (306 pmol/L, z-score: -0.02, P < .001), which was significant after adjusting for age, gender, vitB12 supplement, folate, hemoglobin, leukocytes, liver, and kidney function (P < .02). In ND, 20% (n = 44) had vitB12 above 650 pmol/L, and 1% (n = 3) had below 150 pmol/L (common reference limits). In 6.3% (n = 14) of ND, vitB12 was above 2SD of mean in the age-and gender-adjusted reference population, which was more frequent than in HC (n = 8, 1.6%), OR: 4.0, P = .001. Low vitB12 was equally frequent as in HC, and vitB12 z-scores were equal across the age groups. To conclude, vitB12 was higher in ND than in HC and schizophrenia, suggesting a specific feature of ND, which warrants further studies to investigate the underlying mechanisms.