Neuropsychological abnormalities among HIV-infected individuals in a community-based sample
Neuropsychological abnormalities among HIV-infected individuals in a community-based sample
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DOI：
10.1037/0894-4105.11.4.592
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发表时间：
1997-10-01
期刊：
影响因子：
2.4
通讯作者：
Banks, G
中科院分区：
文献类型：
--
作者：
Becker, JT;Sanchez, J;Banks, G
本研究的目的是确定HIV感染者的神经心理异常的性质和程度，并研究认知功能和预测神经心理异常的因素之间的相互关系。这项研究的重点是在一个多学科研究诊所收集的横截面数据，这些数据来自200名从初级医疗保健机构招募的艾滋病毒感染（HIV）男性和女性。代表六个认知领域的综合得分来自神经心理学测试数据。记忆、流畅性、空间和额叶功能的得分可以通过对参与者的语言和心理速度能力的独立评估来预测。基本言语能力本身是由教育、种族和利手预测的，而速度是由年龄、CD 4+细胞计数和终生重度抑郁症史预测的。这种效应模型与以下假设一致，即精神活动减缓是HIV感染中轻度认知障碍的核心，并且这种变化与全身感染严重程度的标志物相关。
The purpose of this study was to determine the nature and extent of neuropsychological abnormalities among HIV-infected individuals and to examine the interrelationships between measures of cognitive functions and the factors that predict neuropsychological abnormalities. The study focused on cross-sectional data gathered in a multidisciplinary research clinic from 200 HIV-infected (HIVS) men and women recruited from primary medical care settings. Composite scores representing six cognitive domains were derived from the neuropsychological test data. Scores of memory, fluency, spatial, and frontal functions could be predicted by independent assessment of participants' verbal and psychomotor speed abilities. Basic verbal ability itself was predicted by education, race, and handedness, whereas speed was predicted by age, CD4+ cell counts, and a lifetime history of major depression. This model of effects is consistent with the hypothesis that psychomotor slowing is central to mild cognitive disorder in HIV infection and that such changes are associated with markers of the severity of systemic infection.