Application of Flexible OLED Display Technology to Point-of-Care Medical Diagnostic Testing
Application of Flexible OLED Display Technology to Point-of-Care Medical Diagnostic Testing
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DOI：
10.1109/jdt.2015.2479457
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发表时间：
2016-03-01
影响因子：
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通讯作者：
Christen, Jennifer Blain
中科院分区：
文献类型：
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作者：
Smith, Joseph T.;Katchman, Benjamin A.;Christen, Jennifer Blain
本文提出了一种将柔性有机发光二极管（OLED）显示技术与荧光生物识别微阵列技术相结合，制作即时免疫生物传感器的新概念。我们的方法旨在利用商业OLED显示技术，将预功能化生物传感器基板成本降低到每厘米几美分，并利用显示行业每年生产大量低成本消费电子产品的能力。对于这项工作，我们证明了我们的新方法使用高亮度柔性OLED显示技术，结合电荷集成读出电路和光学滤波器，可以提供即时诊断灵敏度等于或低于10 pg/mL，接近典型临床实验室仪器的检测下限（LLOD）。
This paper presents a new concept combining flexible organic light-emitting diode (OLED) display technology with fluorescent biorecognition microarray technology to fabricate point-of-care immunobiosensors. Our approach is designed to leverage commercial OLED display technology to reduce pre-functionalized biosensor substrate costs to pennies per cm combined with leveraging the display industries ability to manufacture an immense number of low-cost consumer electronic products annually. For this work, we demonstrate that our new approach using high brightness flexible OLED display technology combined with a charge integrating readout circuit and optical filters can offer point-of-care diagnostic sensitivity at or below 10 pg/mL, which approaches the lower limit of detection (LLOD) of typical clinical laboratory instrumentation.