Amphiphilic α-helix mimetics based on a benzoylurea scaffold
Amphiphilic α-helix mimetics based on a benzoylurea scaffold
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DOI：
10.1039/c2ob25273b
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发表时间：
2012-01-01
影响因子：
3.2
通讯作者：
Hamilton, Andrew D.
中科院分区：
文献类型：
--
作者：
Thompson, Sam;Hamilton, Andrew D.
设计并合成了两亲性苯甲酰脲类α-螺旋结构模拟物。这些构象受限的分子允许疏水和亲水基团的正确角度和空间投影，从而在α-螺旋的两面上复制侧链。
The design and synthesis of amphiphilic benzoylurea alpha-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an alpha-helix.