Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium
Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium
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DOI：
10.1016/s0196-9781(03)00108-6
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发表时间：
2003-04-01
期刊：
影响因子：
3
通讯作者：
Gutniak, M
中科院分区：
文献类型：
--
作者：
Kavianipour, M;Ehlers, MR;Gutniak, M
胰升糖素样肽-1(7-36)酰胺(GLP-1)已被研究为糖尿病患者的一种治疗选择。在开胸猪心脏模型上，我们研究了重组GLP-1输注对常氧和缺血再灌流过程中血流动力学参数、心肌代谢和梗塞面积的影响。在rGLP-1存在下，缺血和非缺血组织中丙酮酸和乳酸的间质水平在缺血和再灌流期间均降低。此外，rGLP-1输注导致血浆胰岛素水平升高和血糖水平下降。RGLP-1输注对血流动力学指标和随后的脑梗塞范围均无影响。我们的结论是rGLP-1改变了缺血和再灌流期间的心肌葡萄糖利用。它没有产生任何不良的血流动力学影响。(C)2003 Elsevier Science Inc.保留所有权利。
Glucagon-like peptide-1 (7-36) amide (GLP-1) has been studied as a treatment option in diabetic patients. We investigated the effect of recombinant GLP-1 infusion on hemodynamic parameters, myocardial metabolism, and infarct size during normoxic conditions as well as during ischemia and reperfusion using an open-chest porcine heart model. In the presence of rGLP-1, interstitial levels of pyruvate and lactate decreased during ischemia and reperfusion both in ischemic and non-ischemic tissue. Moreover, rGLP-1 infusion resulted in increased plasma insulin levels and decreased blood glucose levels. Neither hemodynamic variables nor the consequent infarct size were influenced by rGLP-1 infusion. We conclude that rGLP-1 altered myocardial glucose utilization during ischemia and reperfusion. It did not exert any untoward hemodynamic effects. (C) 2003 Elsevier Science Inc. All rights reserved.