Nanoparticle technology in bone tissue engineering
Nanoparticle technology in bone tissue engineering
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DOI：
10.1080/10611860701289818
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发表时间：
2007-01-01
影响因子：
4.5
通讯作者：
Fisher, John P.
中科院分区：
文献类型：
--
作者：
Kim, Kyobum;Fisher, John P.
纳米技术已越来越多地用于增强骨组织工程策略。特别是，纳米技术已被用来克服目前与骨再生方法相关的一些限制，包括支架材料的机械强度不足、缺损部位的细胞生长和成骨分化无效，以及刺激骨细胞生长的生长因子的产生不稳定和不足。在生物系统中纳米颗粒的巨大技术中，我们重点关注三个主要的纳米颗粒研究领域，这些领域是为了克服这些限制和缺点而开发的：(a)纳米颗粒复合支架的产生，为骨移植提供更高的机械强度，(b)纳米纤维支架的制造，通过形态有利的结构支持细胞生长和分化，以及(c)开发遗传物质的新型递送和靶向系统，特别是那些编码成骨生长因子的系统。这些基于纳米颗粒的骨组织工程技术在确保临床骨再生功效方面具有巨大潜力。
Nanotechnology has been increasingly utilized to enhance bone tissue engineering strategies. In particular, nanotechnology has been employed to overcome some of the current limitations associated with bone regeneration methods including insufficient mechanical strength of scaffold materials, ineffective cell growth and osteogenic differentiation at the defect site, as well as unstable and insufficient production of growth factors to stimulate bone cell growth. Among the tremendous technologies of nanoparticles in biological systems, we focus here on the three major nanoparticle research areas that have been developed to overcome these limitations and disadvantages: ( a) the generation of nanoparticle- composite scaffolds to provide increased mechanical strength for bone graft, ( b) the fabrication of nanofibrous scaffolds to support cell growth and differentiation through morphologically- favored architectures, and ( c) the development of novel delivery and targeting systems of genetic material, especially those encoding osteogenic growth factors. These nanoparticle- based bone tissue engineering technologies possess a great potential to ensure the efficacy of clinical bone regeneration.