Irisin response to downhill running exercise in humans.
Irisin response to downhill running exercise in humans.
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DOI：
10.20463/jenb.2018.0011
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发表时间：
2018-06-30
期刊：
影响因子：
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通讯作者：
Goto K
中科院分区：
文献类型：
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作者：
Tsuchiya Y;Mizuno S;Goto K
为了确定运动引起的肌肉损伤的影响，我们研究了在同等运动持续时间和耗氧量（CO2）条件下，肌肉损伤较小的水平跑（LR）和肌肉损伤较大的下坡跑（DHR）过程中的鸢尾素反应。15名健康男性（年龄：21.6 ± 2.0岁，身高：170 ± 1.3 cm，体重：64.8 ± 2.7 kg）随机分配至LR组（n = 8）或DHR组（n = 7）。LR组受试者在0%梯度上以70%最大摄氧量（最大吸氧量）进行跑步机跑步30分钟。相比之下，DHR组的受试者在-10%梯度上进行相同的运动。在运动前、运动后即刻、运动后1、3和24 h采集血样。血浆中鸢尾素浓度随时间的变化无显著的交互作用（组×时间）或组或时间的主效应（P > 0.05）。然而，在运动后3 h内，DHR组血浆鸢尾素浓度曲线下面积（239，197 ± 8，166 ng/mL）显著大于LR组（92，293 ± 8，755 ng/ml）（P < 0.05）。运动后，DHR组的血乳酸、血清皮质醇、肌红蛋白和血浆白细胞介素-6浓度均显著高于LR组（P < 0.05）。在相同的VO 2条件下，在相同的持续时间后，与明显的肌肉损伤相关的DHR促进了运动诱导的鸢尾素的更大增加。
To determine the effects of exercise-induced muscle damage, we examined irisin responses during level running (LR), with less muscle damage, and downhill running (DHR), with greater muscle damage under equivalent exercise duration and oxygen consumption (⩒O2) conditions. Fifteen healthy men (age: 21.6 ± 2.0 y, height: 170 ± 1.3 cm, weight: 64.8 ± 2.7 kg) were randomly assigned to either the LR group (n = 8) or the DHR group (n = 7). Subjects in the LR group performed treadmill running at 70% of maximum oxygen uptake (⩒O2max) for 30 min on a 0% gradient. In contrast, subjects in the DHR group performed the same exercise on a –10% gradient. Blood samples were collected before exercise, immediately after exercise, and 1, 3, and 24 h after exercise. No significant interaction (group × time) or main effect of group or time was observed for changes in plasma irisin concentrations over time (P > 0.05). However, the area under the curve of plasma irisin concentrations during a 3-h post-exercise period was significantly greater in the DHR (239,197 ± 8,166 ng/mL) group than in the LR (92,293 ± 8,755 ng/ml) group (P < 0.05). The blood lactate, serum cortisol, myoglobin, and plasma interleukin-6 concentrations were significantly higher in the DHR group than in the LR group after exercise (P < 0.05 for all variables). DHR associated with marked muscle damage promoted a greater increase in exercise-induced irisin did LR after the same duration under identical VO2 conditions.