Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance
Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance
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DOI：
10.1017/s1461145706007073
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发表时间：
2007-06-01
影响因子：
4.8
通讯作者：
Hennig, Juergen
中科院分区：
文献类型：
--
作者：
Reuter, Martin;Kuepper, Yvonne;Hennig, Juergen
在一项遗传关联研究中，我们在404名健康高加索人样本中研究了位于色氨酸羟化酶2基因（TPH 2）启动子区的-703 G/T（rs 4570625）多态性在人格特质中的作用。伤害回避（HA），一种与焦虑相关的特质，和-703G/T多态性之间的显着关联被检测到支持Gutknecht及其同事的发现。
In a genetic association study the role of the -703G/T (rs4570625) polymorphism, located in the promoter region of the tryptophan hydroxylase 2 gene (TPH2), in personality traits was investigated in a sample of 404 healthy Caucasian subjects. A significant association between harm avoidance (HA), a trait related to anxiety, and the -703G/T polymorphism was detected supporting the findings by Gutknecht and colleagues.