Striatal volumes in affected and unaffected relatives of bipolar patients - high-risk study
Striatal volumes in affected and unaffected relatives of bipolar patients - high-risk study
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DOI：
10.1016/j.jpsychires.2008.10.008
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发表时间：
2009-04-01
影响因子：
4.8
通讯作者：
Aida, Martin
中科院分区：
文献类型：
--
作者：
Hajek, Tomas;Gunde, Eva;Aida, Martin
背景：双相情感障碍中报道的纹状体体积变化可能是药物或合并症的产物，或疾病相关的变化，无论是生物倾向还是疾病负担的后果。我们进行了容积高危研究，以调查纹状体容积变化是否为双相情感障碍的主要生物学危险因素。方法：高风险（HR）参与者（年龄范围15-30岁）从双相情感障碍多重影响的家庭中招募。他们包括20名受影响和26名未受影响的父母患有原发性情绪障碍的后代，按年龄和性别匹配，31名没有个人或家族精神疾病史的对照组。采用标准方法在1.5T三维解剖MRI图像上测量纹状体体积。结果：在壳核体积未发生变化的情况下，各组（HR影响组、HR未影响组和对照组）尾状核体积差异有统计学意义（F = 3.50, DF = 2; 74, p = 0.04）。未受影响的HR受试者的尾状核体积最大，在受影响和对照组或受影响和未受影响的HR受试者之间没有差异。最大的变化发生在尾状核的头部。控制每个家庭中多个受试者的非独立性观察结果产生不显著差异。结论：尽管生物学上是合理的，与先前的研究部分一致，并且具有名义上的统计显著性，但控制了家庭内观察的非独立性，使未受影响的受试者的尾状核体积增加变为不显著。因此，我们认为这些发现是负面的，有待进一步的复制。纹状体体积异常不符合本研究的内表型标准。(C) 2008 Elsevier Ltd版权所有。
Background: Striatal volume changes reported in bipolar disorders could represent artifacts of medication or comorbid conditions, or illness related changes, either biological predispositions or consequences of illness burden. We conducted volumetric high-risk study to investigate whether striatal volume changes represent primary biological risk factor for bipolar disorders.Methods: High-risk (HR) participants (age range 15-30 years) were recruited from families multiply affected with bipolar disorders. They included 20 affected and 26 unaffected offspring of parents with primary mood disorders, matched by age and sex with 31 controls without a personal or family history of psychiatric disorders. Striatal volumes were measured on 1.5T 3D anatomical MRI images using standard methods.Results: There was a significant difference between groups (affected, unaffected HR and control subjects) in caudate volumes (F = 3.50, DF = 2; 74 and p = 0.04) in absence of putamen volume changes. The caudate volumes were largest in unaffected HR subjects without differences between affected and control or affected and unaffected HR subjects. The maximum changes were found in the head of the caudate. Controlling for non-independence of observations in multiple subjects per family yielded non-significant differences.Conclusions: Despite the biological plausibility, partial agreement with previous studies and nominal statistical significance, controlling for non-independence of observations within families changed the increased caudate volumes among unaffected subjects to non-significant. We thus present these findings as negative, pending further replication. Striatal volume abnormalities did not meet criteria for endophenotype in this study. (C) 2008 Elsevier Ltd. All rights reserved.