Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130).
Cholesterol metabolism during the growth of a rat ascites hepatoma (Yoshida AH-130).
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DOI：
10.1038/bjc.1992.361
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发表时间：
1992-11
影响因子：
8.8
通讯作者：
Baccino, F M
中科院分区：
文献类型：
--
作者：
Dessi, S;Batetta, B;Anchisi, C;Pani, P;Costelli, P;Tessitore, L;Baccino, F M
在大鼠腹水肝癌（Yoshida AH-130）生长过程中，已经研究了胆固醇的代谢。在肿瘤细胞中观察到胆固醇合成的高速率和升高的游离和酯化的胆固醇含量。在肿瘤生长过程中，宿主动物逐渐发展出明显的血清胆固醇水平和分布变化，包括总胆固醇的升高和HDL胆固醇的明显降低（尤其是HDL2降低）。与以前的观察结果一致，这些发现表明，胆固醇稳态改变的一致模式与正常或肿瘤组织生长有关。在增殖细胞中观察到高合成率和胆固醇的细胞内积累。此外，血清胆固醇在HDL馏分中降低，同时LDL的增加，这表明在组织和血清脂蛋白之间的胆固醇通量在增生过程中明显受到干扰。
The metabolism of cholesterol has been investigated in tumour cells, ascitic fluid and blood serum during the growth of an ascites hepatoma (Yoshida AH-130) in the rat. High rates of cholesterol synthesis and elevated free and esterified cholesterol content were observed in tumour cells. During tumour growth, the host animals progressively developed marked changes in the level and distribution of serum cholesterol consisting in an increase of total cholesterol and of a marked reduction of HDL cholesterol (HDL2 subfraction in particular). In agreement with previous observations, these findings indicate that a consistent pattern of altered cholesterol homeostasis develops in relation to normal or neoplastic tissue growth. High synthetic rates and intracellular accumulation of cholesterol are observed in the proliferating cells. Moreover, blood serum cholesterol decreases in the HDL fraction while it increases in LDLs, suggesting that during proliferative processes cholesterol fluxes between tissues and serum lipoproteins are markedly perturbed.