Differential effects of transection of the spinal cord and splanchnic nerve on adrenal tyrosine hydroxylase and catecholamines
Differential effects of transection of the spinal cord and splanchnic nerve on adrenal tyrosine hydroxylase and catecholamines
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脊髓和内脏神经横断对肾上腺酪氨酸羟化酶和儿茶酚胺的不同影响
DOI：
10.1016/0306-4522(85)90153-8
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发表时间：
1985
期刊：
影响因子：
3.3
通讯作者：
T. Sourkes
中科院分区：
文献类型：
--
作者：
J. Gagner;S. Gauthier;T. Sourkes
在第三胸水平脊髓横断的成年大鼠中研究了脊髓通路在肾上腺髓质酪氨酸羟化酶和儿茶酚胺调节中的作用。在这些动物中，交感肾上腺节前神经元从其脊髓上传入分离。这种治疗导致三天后酪氨酸羟化酶活性和多巴胺含量逐渐降低（与未手术对照组相比），直到至少第10天。对脊髓损伤大鼠给予地塞米松或促肾上腺皮质激素的结果表明，在这些动物中，糖皮质激素分泌过多与肾上腺酪氨酸羟化酶的下降无关，事实上，补充促肾上腺皮质激素可以防止这种下降。（其本身不影响肾上腺酪氨酸羟化酶），在脊髓切片之前，脊髓切断后肾上腺酪氨酸羟化酶和多巴胺的下降可能是由于脊髓切断后对肾上腺的调节冲动减少所致。分散的交感肾上腺节前神经元在离体的脊髓，这些神经元的下行便利的损失和/或这些神经元的节段性神经元间抑制从下行抑制的影响释放。这种下行通路可能交叉部分低于低颈部水平，因为大鼠脊髓半切在C6-C7表现出肾上腺酪氨酸羟化酶或多巴胺的下降，在任何一方术后7天测量。
The role of spinal pathways in the regulation of adrenal medullary tyrosine hydroxylase and catecholamines was studied in adult rats subjected to spinal cord transection at the third thoracic level. In these animals the sympathoadrenal preganglionic neurons were isolated from their supraspinal afferents. This treatment led after three days to a progressive reduction of tyrosine hydroxylase activity and dopamine content (as compared to unoperated controls) until at least the 10th day. The results of the administration of dexamethasone or adrenocorticotropic hormone to spinalized rats suggest that in these animals glucocorticoid hypersecretion is not involved in the decline of adrenal tyrosine hydroxylase and that in fact adrenocorticotropic hormone supplementation can prevent it. A neurogenic origin for the depression of adrenomedullary function is favoured because unilateral splanchnicotomy (which by itself does not affect adrenal tyrosine hydroxylase), prior to cord section, prevented the diminution of tyrosine hydroxylase activity in the denervated gland.The decline of adrenal tyrosine hydroxylase and dopamine after spinal section may result from a decrease of modulatory impulses to the adrenal from decentralized sympathoadrenal preganglionic neurons in the isolated cord, following the loss of a descending facilitation of these neurons and/or the release of a segmental interneuronal inhibition of these neurons from a descending inhibitory influence. Such descending pathways may decussate partially below the low cervical level because rats with hemisection of the cord at C6-C7exhibited no decline of adrenal tyrosine hydroxylase or of dopamine measured on either side seven days postoperatively.
神经元及其效应器官的大分子含量对神经活动的影响。
影响因子：
18.2
作者：
Zigmond,RE;Bowers,CW
通讯作者：
Bowers,CW