No Effect of Selenium Supplementation on Serum Glucose Levels in Men with Prostate Cancer
No Effect of Selenium Supplementation on Serum Glucose Levels in Men with Prostate Cancer
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DOI：
10.1016/j.amjmed.2010.02.018
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发表时间：
2010-08-01
影响因子：
5.9
通讯作者：
Ahmann, Frederick R.
中科院分区：
文献类型：
--
作者：
Algotar, Amit M.;Stratton, Mimi Suzanne;Ahmann, Frederick R.
背景：文献表明硒补充与糖尿病风险之间存在关系。然而，由于这些数据是不确定的，我们研究了硒补充剂对前列腺癌患者血清葡萄糖水平的影响，这些患者参加了一项临床试验，测试硒对前列腺癌进展的影响。方法：受试者随机分为安慰剂组（n = 46）、硒组（n = 47）和硒组（n = 47）。每6个月检测一次血清葡萄糖水平，持续5年。进行了纵向分析，以评估硒补充组的血清葡萄糖水平变化率与安慰剂相比是否有显著差异。进行敏感性分析以评估结果的稳健性。结果：在试验过程中，与安慰剂组相比，硒200 μ g/天（P = 0.56）或硒800 μ g/天（P = 0.91）治疗组的血清葡萄糖水平变化无统计学意义。结论：这些结果不支持硒补充与血清葡萄糖水平变化之间的关系。关于硒补充和糖尿病风险的建议需要更明确的研究。(C) 2010爱思唯尔公司版权所有。《美国医学杂志》（2010）123,765-768
BACKGROUND: Literature indicates a relationship between selenium supplementation and risk of diabetes. However, because these data are inconclusive, we investigated the effect of selenium supplementation on serum glucose levels in men with prostate cancer enrolled in a clinical trial testing of the effect of selenium on prostate cancer progression.METHODS: Subjects were randomized to receive placebo (n = 46), selenium 200 mu g/day (n = 47), and selenium 800 mu g/day (n = 47). Serum glucose levels were obtained every 6 months for up to 5 years. Longitudinal analysis was carried out to assess whether rate of change of serum glucose levels was significantly different in the selenium-supplemented groups as compared with placebo. Sensitivity analyses were performed to assess the robustness of findings.RESULTS: Changes in serum glucose levels during the course of the trial were not statistically significantly different as compared with placebo for the selenium 200 mu g/day (P = .56) or selenium 800 mu g/day (P = .91) treatment groups.CONCLUSION: These results do not support a relationship between selenium supplementation and changes in serum glucose levels. Recommendations about selenium supplementation and risk of diabetes will require more definitive studies. (C) 2010 Elsevier Inc. All rights reserved. center dot The American Journal of Medicine (2010) 123, 765-768