AFRICAN HORSESICKNESS - PATHOGENESIS AND IMMUNITY
AFRICAN HORSESICKNESS - PATHOGENESIS AND IMMUNITY
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DOI：
10.1016/0147-9571(94)90047-7
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发表时间：
1994-08-01
影响因子：
2
通讯作者：
LAEGREID, WW
中科院分区：
文献类型：
--
作者：
BURRAGE, TG;LAEGREID, WW
非洲马病（AHS）是一种严重的非传染性疾病，由呼肠孤病毒科节肢动物传播的环状病毒引起的马和其他单足动物。 在马中，AHS引起三种不同的临床病理学综合征，即肺、心脏和发热形式的疾病。 最近的研究表明，由未感染的马表达的疾病形式的主要决定因素是病毒接种物的毒力。 从AHS恢复的马对同源攻击表现出牢固的体液免疫。 保护性抗体似乎针对AHS病毒VP2上的中和表位。 讨论了中和与保护和疫苗接种的关系。
African horsesickness (AHS) is a serious, non-contagious disease of horses and other solipeds caused by an arthropod-borne orbivirus of the family Reoviridae. In horses, AHS causes three distinct clinicopathologic syndromes, the pulmonary, cardiac and fever forms of the disease. Recent work has shown that the primary determinant of the form of disease expressed by naive horses is the virulence of the virus inoculum. Horses which recover from AHS exhibit solid humoral immunity against homologous challenge. Protective antibodies appear to be directed towards neutralizing epitopes on AHS virus VP2. The relationship of neutralization to protection and vaccination is discussed.