Arterial regulators taken up by lymphatics.
Arterial regulators taken up by lymphatics.
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动脉调节器被淋巴管占据。
DOI：
10.1089/lrb.2008.1024
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发表时间：
2008
影响因子：
1.4
通讯作者：
Kitajewski,Jan
中科院分区：
文献类型：
--
作者：
Shawber,CarrieJ;Kitajewski,Jan
我们提出了三个例子的关键基因的功能，动脉规格，最近被牵连在淋巴发育; ephrinB 2，FoxC 2和Notch。在动脉细胞命运决定中，Foxc 2调节Notch和Notch配体表达。反过来，动脉中的Notch信号激活驱动ephrinB 2的表达。这将是有趣的，以确定是否在动脉发育中发现的这些途径之间的调节关系是相关的了解淋巴发育，也就是说，我们问动脉调节因子是否也是淋巴发育的关键调节因子。
We present three examples of key genes that function in arterial specification that have recently been implicated in lymphatic development; ephrinB2, FoxC2, and Notch. In arterial cell fate determination, Foxc2 regulates both Notch and Notch ligand expression. In turn, Notch signal activation in arteries drives expression of ephrinB2. It will be interesting to determine if the regulatory relationships between these pathways found in arterial development are relevant to understanding lymphatic development, that is, we ask whether arterial regulators are also key regulators of lymphatic development.