White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.
White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults.
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DOI：
10.1016/j.neurobiolaging.2014.04.030
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发表时间：
2014-10
影响因子：
4.2
通讯作者：
Smith CD
中科院分区：
文献类型：
--
作者：
Gold BT;Zhu Z;Brown CA;Andersen AH;LaDu MJ;Tai L;Jicha GA;Kryscio RJ;Estus S;Nelson PT;Scheff SW;Abner E;Schmitt FA;Van Eldik LJ;Smith CD
我们探讨了认知正常（CN）老年人的白色物质（WM）完整性是否与阿尔茨海默病（AD）病理学的脑脊液（CSF）标志物相关。20名CN老年人在几天内接受了腰椎穿刺和磁共振成像。扩散张量成像数据的分析涉及先验感兴趣区域（ROI）和体素方法。ROI结果显示，CSF中β淀粉样蛋白（Aβ42和Aβ42/p-Tau 181）测量值与穹窿WM完整性呈正相关，在控制海马体积和穹窿体积后，这种关系仍然存在。穹窿同一部分的WM完整性较低也与数字符号测试的性能降低相关。随后的探索性体素分析表明，CSF Aβ42/p-Tau 181与穹窿、上级纵束、额枕下束的双侧部分以及胼胝体和左下纵束中的WM完整性呈正相关。我们的研究结果链接较低的WM微结构完整性CN老年人与脑脊液生物标志物的AD，并表明，这种关联在穹窿可能是独立的体积措施。
We explored whether white matter (WM) integrity in cognitively normal (CN) older adults is associated with cerebrospinal fluid (CSF) markers of Alzheimer’s disease (AD) pathology. Twenty CN older adults underwent lumbar puncture and magnetic resonance imaging within a few days of each other. Analysis of diffusion tensor imaging data involved a priori region of interest (ROI) and voxelwise approaches. The ROI results revealed a positive correlation between CSF measures of amyloid-beta (Aβ42 and Aβ42/p-Tau181) and WM integrity in the fornix, a relationship which persisted after controlling for hippocampal volume and fornix volume. Lower WM integrity in the same portion of the fornix was also associated with reduced performance on the Digit Symbol test. Subsequent exploratory voxelwise analyses indicated a positive correlation between CSF Aβ42/p-Tau181 and WM integrity in bilateral portions of the fornix, superior longitudinal fasciculus, inferior fronto-occipital fasciculus, and in the corpus callosum and left inferior longitudinal fasciculus. Our results link lower WM microstructural integrity in CN older adults with CSF biomarkers of AD and suggest that this association in the fornix may be independent of volumetric measures.
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DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
9.9
作者：
Jack, CR;Petersen, RC;Kokmen, E
通讯作者：
Kokmen, E
影响因子：
2.4
作者：
Englund, E
通讯作者：
Englund, E
影响因子：
--
作者：
Dickerson, Bradford C.;Sperling, Reisa A.;Blacker, Deborah
通讯作者：
Blacker, Deborah
影响因子：
4.2
作者：
Bartzokis G
通讯作者：
Bartzokis G