Generic nature of the condensed states of proteins
Generic nature of the condensed states of proteins
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DOI：
10.1038/s41556-021-00697-8
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发表时间：
2021-06-01
影响因子：
21.3
通讯作者：
Vendruscolo, Michele
中科院分区：
文献类型：
--
作者：
Fuxreiter, Monika;Vendruscolo, Michele
经历液-液相分离的蛋白质正以越来越快的速度被发现。由于在细胞中存在的高浓度下，预期大多数蛋白质将形成液体凝聚态，因此这种状态应被认为是蛋白质的基本状态，与天然状态和淀粉样蛋白状态一起沿着。在这里，我们讨论了类液体和类固体的凝聚态的一般性质，并描述了各种各样的生物功能赋予这些凝聚态。在这个角度来看，Fuxreiter和Vendruscolo讨论的基本性质的液滴和淀粉样蛋白状态的蛋白质，控制其形成的调节机制，以及与这些凝聚态的细胞功能。
Proteins undergoing liquid-liquid phase separation are being discovered at an increasing rate. Since at the high concentrations present in the cell most proteins would be expected to form a liquid condensed state, this state should be considered to be a fundamental state of proteins along with the native state and the amyloid state. Here we discuss the generic nature of the liquid-like and solid-like condensed states, and describe a wide variety of biological functions conferred by these condensed states.In this Perspective, Fuxreiter and Vendruscolo discuss the fundamental nature of the droplet and amyloid states of proteins, the regulatory mechanisms controlling their formation, and the cellular functions associated with these condensed states.