Treatment of Infected Soft Tissue Blast Injury in Swine by Regulated Negative Pressure Wound Therapy
Treatment of Infected Soft Tissue Blast Injury in Swine by Regulated Negative Pressure Wound Therapy
复制标题
通过调节负压伤口疗法治疗猪感染性软组织爆炸伤。
DOI：
10.1097/sla.0b013e318269d1ca
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发表时间：
2013-02-01
影响因子：
9
通讯作者：
Li, Xueyong
中科院分区：
文献类型：
--
作者：
Li, Jinqing;Topaz, Morris;Li, Xueyong
目的：本研究的目的是调查的治疗潜力的调节负压伤口治疗（RNPT）在治疗感染的冲击伤instein.Background：约30%至80%的冲击伤发展感染，这增加了发病率和死亡率的伤亡。RNPT已被用于美国在伊拉克的军事行动，但是，没有随机对照研究已经进行了使用RNPT治疗感染war injuries.Methods：感染的软组织爆炸伤纱布敷料或RNPT治疗不同的压力范围从-5到-35 kPa。为了评价伤口愈合过程，在不同时间点测量伤口面积、伤口深度、肉芽组织中增殖细胞的数量和血管内皮细胞。结果：与纱布敷料相比，RNPT能更有效地降低创面细菌负荷，更早地启动肉芽组织形成，更快地促进炎症反应。RNPT组在-10 ~-25kPa范围内施加负压，对治疗感染的软组织冲击伤具有有益的效果。RNPT并没有显着改变的好氧和厌氧细菌的组成与纱布敷料group.Conclusions：RNPT清楚地显示出有益的效果，在治疗感染的软组织爆炸伤相比，纱布敷料治疗在猪。
Objective: This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected blast injuries in swine.Background: Approximately 30% to 80% of blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries.Methods: Infected soft tissue blast injuries were treated with gauze dressings or RNPT with different pressures ranging from -5 to -35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the blast injury, the bacterial load, bacterial species, and several inflammatory markers were detected.Results: Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from -10 to -25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue blast injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group.Conclusions: RNPT clearly shows beneficial effects in treating the infected soft tissue blast injury in comparison with the gauze dressing therapy in swine.