Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions.
Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions.
复制标题
接受减肥干预的肥胖患者糖尿病缓解的代谢特征。
DOI：
10.1002/oby.23943
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
LookAHEADResearchGroup
中科院分区：
文献类型：
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作者：
Thaker,VidhuV;Kwee,LydiaCoulter;Chen,Haiying;Bahnson,Judy;Ilkayeva,Olga;Muehlbauer,MichaelJ;Wolfe,Bruce;Purnell,JonathanQ;Pi-Sunyer,Xavier;Newgard,ChristopherB;Shah,SvatiH;Laferrère,Blandine;LookAHEADResearchGroup
目的观察2型糖尿病(T2D)患者体重减轻后的代谢变化。我们假设与T2D相关表型相关的代谢物变化是健康改善的标志。方法从接受减肥手术(n= 71 Roux-en-Y胃旁路，n= 22胃束带)、生活方式干预(n= 66)或日常护理(n= 14)的个体的空腹血浆样本中分析减重前和减肥后2 年的139种代谢物。主成分分析将相关的代谢物归类为因子。通过干预前的临床特征和T2D标志物的变化来检验干预前代谢产物的相关性。评价代谢产物/代谢因子的变化与T2D缓解标志物的变化、β细胞功能的稳态模型评估、胰岛素抵抗的稳态模型评估以及糖化血红蛋白(HbA1c)。结果支链氨基酸与干预前肥胖相关。支链氨基酸(Valine、亮氨酸/异亮氨酸)和支链酮酸的变化与HbA1c(假发现率q值 ≤ 0.001)的变化呈正相关，在调整体重变化百分比和RYGB后仍持续存在(p≤ 0.02)。在按RYGB或其他减重方法分层的分析中，一些代谢物显示与非RYGB减重有关。结论本研究证实了已知的代谢物与肥胖/T2D相关，并显示BCAA与减重后HbA1c的变化有关，与减重方法或减重幅度无关。
ObjectiveThis observational study investigated metabolomic changes in individuals with type 2 diabetes (T2D) after weight loss. We hypothesized that metabolite changes associated with T2D‐relevant phenotypes are signatures of improved health.MethodsFasting plasma samples from individuals undergoing bariatric surgery (n= 71 Roux‐en‐Y gastric bypass [RYGB],n= 22 gastric banding), lifestyle intervention (n= 66), or usual care (n= 14) were profiled for 139 metabolites before and 2 years after weight loss. Principal component analysis grouped correlated metabolites into factors. Association of preintervention metabolites was tested with preintervention clinical features and changes in T2D markers. Association between change in metabolites/metabolite factors and change in T2D remission markers, homeostasis model assessment of β‐cell function, homeostasis model assessment of insulin resistance, and glycated hemoglobin (HbA1c) was assessed.ResultsBranched‐chain amino acids (BCAAs) were associated with preintervention adiposity. Changes in BCAAs (valine, leucine/isoleucine) and branched‐chain ketoacids were positively associated with change in HbA1c (false discovery rateqvalue ≤ 0.001) that persisted after adjustment for percentage weight change and RYGB (p≤ 0.02). In analyses stratified by RYGB or other weight loss method, some metabolites showed association with non‐RYGB weight loss.ConclusionsThis study confirmed known metabolite associations with obesity/T2D and showed an association of BCAAs with HbA1c change after weight loss, independent of the method or magnitude of weight loss.