Liver enzymes and metabolic syndrome: a large-scale case-control study.
Liver enzymes and metabolic syndrome: a large-scale case-control study.
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肝酶和代谢综合征：大规模病例对照研究。
DOI：
10.18632/oncotarget.5792
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发表时间：
2015-09-29
期刊：
影响因子：
--
通讯作者：
Xiong H
中科院分区：
文献类型：
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作者：
Zhang L;Ma X;Jiang Z;Zhang K;Zhang M;Li Y;Zhao X;Xiong H
先前的研究表明，肝酶升高可以作为代谢综合征（MetS）及其临床结果的潜在新型生物标志物，尽管结果不一致且结论缺乏说服力。对 6,268 名 MetS 受试者和 6,330 名频率匹配的健康对照进行了病例对照研究，系统评估了总体人群和肝酶正常受试者的四种肝酶（ALT、AST、GGT 和 ALP）水平，并使用肝酶四分位数和连续单位来评估 MetS 风险。我们发现上述所有分析都检测到显着的关联。与四分位数 1 (Q1) 相比，其他四分位数的 MetS 风险显着较高，OR 范围为 1.15 至 18.15。检测到 GGT 受影响最大，最高四分位数与最低四分位数的 OR 值为 18.15（95% CI：15.7-20.9）。相互调节证明了四种肝酶之间关系的独立性。敏感性分析并没有实质性改变这一趋势。据我们所知，这项研究应该是规模最大的研究，旨在评估肝酶测量与 MetS 风险之间的关联。结果可以更好地支持肝酶水平可以用作 MetS 的临床预测因子。
Previous studies suggested that elevated liver enzymes could be used as potential novel biomarkers of Metabolic syndrome (MetS) and its clinical outcomes, although the results were inconsistent and the conclusions were underpowered. A case-control study with 6,268 MetS subjects and 6,330 frequency-matched healthy controls was conducted to systematically evaluated levels of four liver enzymes (ALT, AST, GGT and ALP), both in overall populations and in subjects with normal liver enzymes, with MetS risk using both quartiles and continuous unit of liver enzymes. We found significant associations were detected for all above analyses. Compared with quartile 1 (Q1), other quartiles have significant higher MetS risk, with ORs ranging from 1.15 to 18.15. The highest effected was detected for GGT, for which the OR value for the highest versus lowest quartile was 18.15 (95% CI: 15.7-20.9). Mutual adjustment proved the independence of the relations for all four liver enzymes. Sensitivity analyses didn’t materially changed the trend. To the best of our knowledge, this study should be the largest, which aimed at evaluating the association between liver enzymes measures and MetS risk. The results can better support that liver enzyme levels could be used as clinical predictors of MetS.