Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer
Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer
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DOI：
10.1016/j.ejrad.2016.12.034
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发表时间：
2017-03-01
影响因子：
3.3
通讯作者：
Covello, Mario
中科院分区：
文献类型：
--
作者：
Cavaliere, Carlo;Romeo, Valeria;Covello, Mario
目的：评估组织学证实的喉癌患者代谢 18 氟脱氧葡萄糖正电子发射断层扫描 (18FDG/PET) 与磁共振成像 (MRI) 得出的形态功能参数之间的关系。旨在评估 PET/MRI 检查对患者分期和治疗计划的临床影响。方法：纳入 16 名经组织学证实为喉癌的患者，接受全身 PET/CT，随后进行头颈部专用 PET/MRI。数据由两个盲组分别评估：通过定位感兴趣区域（ROI）获得代谢（SUV 和 MTV）、扩散（ADC）和灌注（K-trans、V-e、k(ep) 和 iAUC）图。将 PET/MRI 评估的肿瘤局部扩展与内窥镜检查结果进行比较。结果：观察者之间在 PET/MRI 病变的解剖位置和局部扩展方面具有良好的一致性（Cohen's kappa 0.9）。 PET/CT SUV 测量值与 PET/MRI 得出的测量值高度相关（例如，VOI 测量值 p = 0.96）。已检测到代谢、扩散和灌注参数之间的显着相关性。 PET/MRI 具有相关的临床影响，确认内镜检查结果（6 例），帮助制定治疗计划（9 例），并修改内镜初步分期（1 例）。结论：PET/MRI 可用于喉癌的初步分期，允许同时收集代谢和功能数据并调整治疗策略。 (C) 2016 Elsevier Ireland Ltd. 保留所有权利。
Objectives: To evaluate the relationship between metabolic 18Fluoro-Deoxyglucose-Positron Emission Tomography (18FDG/PET) and morpho-functional parameters derived by Magnetic Resonance Imaging(MRI) in patients with histologically proven laryngeal cancer. To assess the clinical impact of PET/MRI examination on patient's staging and treatment planning.Methods: 16 patients with histologically proven laryngeal cancer were enrolled and underwent whole body PET/CT followed by a dedicated PET/MRI of the head/neck region. Data were separately evaluated by two blinded groups: metabolic (SUV and MTV), diffusion (ADC) and perfusion (K-trans, V-e, k(ep) and iAUC) maps were obtained by positioning regions of interest (ROIs). Tumoral local extension assessed on PET/MRI was compared to endoscopic findings.Results: A good inter-observer agreement was found in anatomical location and local extension of PET/MRI lesions (Cohen's kappa 0.9). PET/CT SUV measures highly correlate with ones derived by PET/MRI (e.g., p = 0.96 for measures on VOI). Significant correlations among metabolic, diffusion and perfusion parameters have been detected. PET/MRI had a relevant clinical impact, confirming endoscopic findings (6 cases), helping treatment planning (9 cases), and modifying endoscopic primary staging (1 case).Conclusions: PET/MRI is useful for primary staging of laryngeal cancer, allowing simultaneous collection of metabolic and functional data and conditioning the therapeutic strategies. (C) 2016 Elsevier Ireland Ltd. All rights reserved.