Disentangling chromatin architecture to gain insights into the etiology of brain disorders.
Disentangling chromatin architecture to gain insights into the etiology of brain disorders.
复制标题
解开染色质结构，深入了解大脑疾病的病因。
DOI：
10.1016/j.gde.2019.06.009
复制
发表时间：
2019
影响因子：
4
通讯作者：
Zhou,Zhaolan
中科院分区：
文献类型：
--
作者：
Lamonica,JanineM;Zhou,Zhaolan
Chromatin organization, together with DNA and histone modifications, is directly linked to the spatiotemporal control of gene expression that specifies and maintains cell type-specific functions. This is particularly important in the brain where hundreds of cell types with distinct functions reside. Recent advances in molecular and computational technologies have enabled the query of chromatin architecture at unprecedented resolution and detail. Here, we review recent studies on the emerging importance of chromatin architecture in the pathogenesis of brain disorders, with emphasis on schizophrenia, autism spectrum disorders (ASD), and unstable repeat expansion disorders. These studies provide molecular insights into how these brain disorders arise at the level of chromatin architecture and implicate new therapeutic directions.
