The effect of intravenous interleukin-2 on brain water content.
The effect of intravenous interleukin-2 on brain water content.
复制标题
静脉注射白细胞介素2对脑含水量的影响。
作者：
S. Saris;N. Patronas;S. Rosenberg;J. Alexander;J. Frank;D. Schwartzentruber;J. Rubin;D. Barba;E. Oldfield
用白细胞介素-2（IL-2）进行肠外治疗对中枢神经系统以外的某些晚期癌症有效。在脑肿瘤患者的II期试验开始之前，研究了10例接受重复剂量IL-2静脉给药治疗的患者的神经学和神经放射学特征。三名患者患有恶性胶质瘤，七名患者患有颅外癌，没有颅内转移的证据。所有患者均接受静脉给药，剂量为10（5）U/kg，每日3次，持续5天。胶质瘤患者在IL-2治疗开始前和治疗后期接受头颅计算机轴向断层扫描（CT）。颅外肿瘤患者在治疗前和治疗后期进行T2加权磁共振成像。在2至11次剂量的IL-2后，患有胶质瘤的患者具有显著的神经功能恶化，其与肿瘤周围水肿的轻度至显著增加以及CT扫描上可见的肿块效应相关。停止治疗和适当的支持性护理后，所有患者均恢复至治疗前状态。颅外癌患者的神经功能没有改变，或者精神状态发生了轻微的短暂变化（嗜睡和意识模糊）。在这些患者中，MR信号强度进行了量化和比较，在八个解剖区域的利益。在7名患者中的6名中，灰色和白色物质信号强度增加与脑含水量增加一致。灰质和白色物质的百分比变化（平均值+/-平均值的标准误差）分别为12.6% +/- 7.3%和17.0% +/- 6.2%。这项研究表明，由于脑水肿增加，神经胶质瘤患者不能耐受高剂量的IL-2治疗。在患有颅外癌但无脑部疾病的患者中，肠外IL-2诱导灰质和白色物质的脑含水量增加。
Parenteral treatment with interleukin-2 (IL-2) is effective against certain advanced cancers outside the central nervous system. Prior to commencement of Phase II trials in patients with brain tumors, the neurological and neuroradiological features of 10 patients treated with intravenous administration of repeated doses of IL-2 were studied. Three patients had malignant gliomas, and seven patients had extracranial cancer without evidence of intracranial metastasis. All were treated with intravenous doses of 10(5) U/kg three times daily for up to 5 days. The patients with gliomas received cranial computerized axial tomography (CT) scans before IL-2 therapy was initiated and during the later stages of treatment. The patients with extracranial cancer underwent T2-weighted magnetic resonance (MR) imaging before and later during therapy. After two to 11 doses of IL-2, the patients with gliomas had marked neurological deterioration that was associated with a mild to marked increase in peritumoral edema and mass effect visible on CT scans. With cessation of treatment and appropriate supportive care, all returned to their pretreatment state. The patients with extracranial cancer were either neurologically unchanged or underwent minor transient changes in mental status (lethargy and confusion). In these patients, the MR signal intensity was quantified and compared in eight anatomic regions of interest. In six of the seven patients, there were increases in gray and white matter signal intensity consistent with increased cerebral water content. The percentage changes (means +/- standard error of the means) were 12.6% +/- 7.3% in the gray matter and 17.0% +/- 6.2% in the white matter. This study demonstrates that treatment with a high parenteral dose of IL-2 is not tolerated by patients with gliomas due to increased cerebral edema. In patients with extracranial cancer but no brain disease, parenteral IL-2 induces an increase in the cerebral water content of both gray and white matter.
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白细胞介素 2 刺激的淋巴细胞的运动性和杀肿瘤活性。
影响因子：
11.2
作者：
Ratner,S;Heppner,GH
通讯作者：
Heppner,GH
重组白细胞介素 2 输注后猫的血脑屏障功能障碍。
影响因子：
11.2
作者：
Ellison,MD;Povlishock,JT;Merchant,RE
通讯作者：
Merchant,RE
原发性颅内肿瘤的免疫生物学。
影响因子：
4.1
作者：
MahaleyJr,MS;Steinbok,P;Aronin,P;Dudka,L;Zinn,D
通讯作者：
Zinn,D
白细胞介素 2 免疫治疗期间的内皮激活。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cotran,RS;Pober,JS;GimbroneJr,MA;Springer,TA;Wiebke,EA;Gaspari,AA;Rosenberg,SA;Lotze,MT
通讯作者：
Lotze,MT