DEMONSTRATION OF NATURALISTIC METHODS FOR COCAINE SMOKING BY HUMAN VOLUNTEERS
DEMONSTRATION OF NATURALISTIC METHODS FOR COCAINE SMOKING BY HUMAN VOLUNTEERS
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DOI：
10.1016/0376-8716(90)90121-t
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发表时间：
1990-10-01
影响因子：
4.2
通讯作者：
PEARLSON, GD
中科院分区：
文献类型：
--
作者：
FOLTIN, RW;FISCHMAN, MW;PEARLSON, GD
五名健康的成年男性研究志愿者在临床研究单位居住期间参加了多达四次的日常实验室会议。两名受试者接受两次治疗。每次吸食 50 毫克可卡因碱 1 次、2 次或 4 次，两次吸食之间间隔 14 分钟。两名受试者吸食放置在“无烟”香烟中的可卡因，而其余受试者则吸食放置在改良烟斗中的可卡因。使用改良的烟斗最一致地产生了显着且具有生物学相关性的可卡因静脉血浓度。在单次给药过程中观察到心率、血压和自我报告的“刺激”评分出现大幅、短暂的增加。在多次给药期间，心血管活动要么增加，在两次给药之间恢复到接近基线水平，要么持续存在，而报告的“刺激”分数在第一次给药后达到峰值，并在后续剂量后降低。可卡因血液浓度曲线的上升肢对心血管和主观影响均大于下降肢，表明急性耐受性。虽然是初步的，但这些结果证明了这种相对简单的程序的有用性，要求受试者以他们习惯的方式吸烟，并表明在这一领域进一步研究的重要性。
Five, healthy, adult, male research volunteers participated in up to four daily laboratory sessions while residing on a Clinical Research Unit. Two subjects were treated twice. Fifty milligrams of cocaine base was smoked one, two or four times each session with a 14-min interval between doses. Two subjects smoked cocaine placed in ''smoke-free'' cigarettes, while the remaining subjects smoked cocaine placed in a modified tobacco pipe. Significant and biologically relevant cocaine venous blood levels were engendered most consistently using the modified tobacco pipe. Large, transient increases in heart rate, blood pressure and self-reported ''stimulated'' scores were observed during single dosing sessions. During multiple dose sessions, cardiovascular activity either increased, returning to near baseline levels between doses, or were sustained, while reported ''stimulated'' scores peaked after the first dose and were lower following subsequent doses. Both cardiovascular and subjective effects were greater on the ascending limb than on the descending limb of the cocaine blood level curve suggesting acute tolerance. Although preliminary, these results demonstrate the usefulness of this relatively simple procedure requiring subjects to smoke in the manner they are accustomed, and suggest the importance of further research in this area.