Umbilical venous blood flow measurement:: accuracy and reproducibility
Umbilical venous blood flow measurement:: accuracy and reproducibility
复制标题
DOI：
10.1002/uog.5306
复制
发表时间：
2008-09-01
影响因子：
7.1
通讯作者：
Gratacos, E.
中科院分区：
文献类型：
--
作者：
Figueras, F.;Fernandez, S.;Gratacos, E.
脐静脉血流量可以被认为是血管胎盘功能的直接生理测量，代表到达胎儿的氧气和营养物质的量。高科技超声波和脉冲多普勒的出现克服了早期研究的一些局限性。事实上，与体内血流计算的几个黄金标准相比，脐静脉血流的多普勒测量被发现是准确的。然而，体积流量分量、血管面积和平均速度中的小误差会导致体积流量计算中的大误差。因此，技术标准化至关重要。动物模型的验证研究已经证明，通过从绳索自由浮动部分的纵向截面的垂直视图估计血管的横截面积，可以准确地测量静脉血流量。另一方面，从最大速度估计平均速度，而不是使用强度加权平均速度，对软件的依赖性较小，并且定义更清晰，从而产生具有更可预测和系统误差的估计。通过遵循严格的方法学建议，脐静脉血流量计算具有中度至良好的观察者内和观察者间再现性。脐静脉流量测量的准确性和可重复性已被证实，还需要进一步研究来确定其临床价值。版权所有 (C) 2008 ISUOG。由约翰·威利父子有限公司出版
Umbilical venous blood flow could be considered a direct and physiological measurement of vascular placental function, representing the quantity of oxygen and nutrients reaching the fetus. The advent of high-technology ultrasound and pulsed Doppler has overcome some of the limitations of early studies. Indeed, Doppler measurement of umbilical venous blood flow has been found to be accurate when compared with several gold standards for in-vivo flow calculation. Nevertheless, small errors in volume flow components, the vessel area and the mean velocity, result in large errors in the calculation of volume flow. Therefore, technique standardization is of paramount importance. Validation studies in animal models have demonstrated accurate venous blood flow measurements by estimating the vessel's cross-sectional area from perpendicular views of longitudinal sections of free-floating portions of the cord. On the other hand, estimation of the mean velocity from the maximum velocity, rather than using the intensity-weighted mean velocity, is less software-dependent and more clearly defined, yielding estimates with more predictable and systematic errors. By adhering to stringent methodological recommendations, umbilical venous blood flow calculation has moderate to good intra- and interobserver reproducibility. Having been found to be accurate and reproducible, further studies are required to establish the clinical value of umbilical vein flow measurement. Copyright (C) 2008 ISUOG. Published by John Wiley & Sons, Ltd.