Surface treatments and roughness properties of Ti-based biomaterials
Surface treatments and roughness properties of Ti-based biomaterials
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DOI：
10.1023/b:jmsm.0000042679.28493.7f
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发表时间：
2004-09-01
影响因子：
3.7
通讯作者：
Di Bello, C
中科院分区：
文献类型：
--
作者：
Bagno, A;Di Bello, C
如今，植入装置的使用在矫形外科和牙科外科领域是一种公认的做法。科学研究和临床经验表明，这些装置的成功开发主要依赖于骨整合，被认为是解剖学上的一致性和承载能力。事实上，骨整合过程受到多种因素的影响：解剖位置、种植体的大小和设计、手术操作、负荷效应、生物体液、年龄和性别，尤其是表面特征。为此，人们一直在尝试改变种植体表面的成分和形态，以优化种植体与骨的接触并改善整合。植入材料与生物环境之间的初步相互作用被认为是由表面属性控制的，它们控制着细胞在表面的粘附量和质量，从而控制细胞/组织的生长。因此，表面性质决定了新骨组织的形成和种植体的骨整合。本文综述了钛基生物材料在生物医学设备生产中常用的物理、化学和生物化学处理的研究现状。特别是，研究了由物理和化学技术引起的粗糙度特征；也考虑了通过生物化学功能化手段开发具有生物活性的表面。(C)2004年克鲁沃学术出版社。
Nowadays, the use of implanted devices is a well-acknowledged practice in the field of orthopaedic and dental surgery. Scientific research and clinical experience suggest that the successful exploitation of these devices mainly depends on osseointegration, considered as both anatomical congruency and load-bearing capacity. Indeed, the osseointegration process is influenced by a wide range of factors: anatomical location, implant size and design, surgical procedure, loading effects, biological fluids, age and sex, and, in particular, surface characteristics. For this reason, several attempts have been aimed at modifying implant surface composition and morphology to optimise implant-to-bone contact and improve integration.Preliminary interactions between implanted materials and biological environment are deemed to be governed by the surface properties; they control the amount and quality of cell adhesion on the surface and, consequently, cell/tissue growth. Thus, surface properties govern new bone tissue formation and implant osseointegration.This paper reviews the state of art in the field of physical, chemical and biochemical treatments commonly used on Ti-based biomaterials for the production of biomedical devices. In particular, roughness characteristics due to physical and chemical techniques are investigated; the development of biologically active surfaces by means of biochemical functionalisation is also considered. (C) 2004 Kluwer Academic Publishers.