microRNAs in rheumatoid arthritis: midget RNAs with a giant impact
microRNAs in rheumatoid arthritis: midget RNAs with a giant impact
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DOI：
10.1136/ard.2010.140152
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发表时间：
2011-02
影响因子：
27.4
通讯作者：
J. Wittmann;H. Jäck
中科院分区：
文献类型：
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作者：
J. Wittmann;H. Jäck
MicroRNAs （miRNAs）是一种微小的非编码分子，主要通过与相应mrna的3 ' -非翻译区互补序列杂交，在转录后水平调节基因表达。根据沃森-克里克碱基配对的程度，miRNA要么加速相应转录物的降解，要么限制其翻译。有令人信服的证据表明，miRNA在控制和调节免疫中起着至关重要的作用，而miRNA的失调可导致自身免疫并促进肿瘤发生，使miRNA调节成为免疫和肿瘤发生之间的平衡行为。本研究的重点是mirna在类风湿关节炎（RA）的建立和维持中的作用，类风湿关节炎是一种具有不可逆关节破坏的系统性炎症性自身免疫性疾病。本文概述了mirna在RA中的已知功能，以及这些小RNA分子在RA诊断和治疗中的应用前景。
MicroRNAs (miRNAs) are tiny, non-coding molecules that primarily modulate gene expression at the post-transcriptional level by predominantly hybridising to complementary sequences in the 3′-untranslated region of their corresponding mRNAs. Depending on the degree of Watson–Crick base pairing, a miRNA either accelerates the degradation of the corresponding transcript or restricts its translation. There is compelling evidence that miRNAs have crucial roles in controlling and modulating immunity, while dysregulation of miRNAs can lead to autoimmunity and promote tumourigenesis, making miRNA regulation a balancing act between immunity and tumourigenesis. Here, the focus is on the role of miRNAs during the establishment and sustainment of rheumatoid arthritis (RA), a systemic, inflammatory autoimmune disease with irreversible joint destruction. An overview of the known function of miRNAs in RA and what the future might hold for the use of these small RNA molecules in RA diagnosis and treatment is provided.