Sodium citrate ingestion protocol impacts induced alkalosis, gastrointestinal symptoms, and palatability
Sodium citrate ingestion protocol impacts induced alkalosis, gastrointestinal symptoms, and palatability
复制标题
柠檬酸钠摄入方案会影响诱发性碱中毒、胃肠道症状和适口性
作者：
Charles S. Urwin;R. Snow;L. Orellana;Dominique Condo;G. Wadley;A. Carr
比较以溶液或胶囊形式摄入 500 mg·kg−1 体重 (BM) 柠檬酸钠对诱发碱中毒、胃肠道症状和适口性的影响。 24 名健康活跃的参与者完成了两次测试，摄入 500 mg·kg−1 BM 柠檬酸钠溶液或胶囊。摄入前采集毛细血管血样，摄入后 240 分钟内每 30 分钟采集一次毛细血管血样；分析样本的血液 pH 值和 [HCO3−]。使用经过验证的问卷以相同的 30 分钟间隔量化胃肠道症状。摄入后立即使用经过验证的量表对适口性进行量化。与溶液相比，胶囊的血液 pH 值 (P < 0.001) 和 [HCO3−] (P = 0.013) 的峰值和相对基线的变化更大。服用胶囊后，血液 pH 值和 [HCO3−] 达到峰值的时间分别为 199 分钟和 204 分钟，均显着晚于溶液后（P = 0.034，P = 0.001）。在摄入后 30 至 120 分钟之间的每个时间点，两种摄入模式的胃肠道症状均显着高于基线（P = 0.003），而在任何时间点模式之间没有差异（P = 0.644）。胶囊明显比溶液更适口（P < 0.001）。我们建议在运动前至少 200 分钟摄入 500 mg·kg−1 BM 柠檬酸钠胶囊，以实现更大程度的碱中毒，最大限度地减少胃肠道症状。
To compare the effect of 500 mg·kg−1 body mass (BM) sodium citrate ingested in solution or capsules on induced alkalosis, gastrointestinal symptoms and palatability. Twenty‐four healthy and active participants completed two testing sessions, ingesting 500 mg·kg−1 BM sodium citrate within solution or capsules. Capillary blood samples were collected pre‐ingestion, and every 30‐min for 240‐min post‐ingestion; samples were analyzed for blood pH and [HCO3−]. A validated questionnaire was used to quantify gastrointestinal symptoms at the same 30‐min intervals. Palatability was quantified immediately after ingestion using a validated scale. There was a greater peak and change from baseline for capsules versus solution for blood pH (P < 0.001) and [HCO3−] (P = 0.013). Blood pH and [HCO3−] time to peak was 199 and 204 min, respectively, after capsule ingestion, both significantly later than after solution (P = 0.034, P = 0.001). Gastrointestinal symptoms were significantly elevated above baseline for both ingestion modes at each time point between 30 and 120 min after ingestion (P = 0.003), with no differences between modes at any time point (P = 0.644). Capsules were significantly more palatable than solution (P < 0.001). We recommend 500 mg·kg−1 BM sodium citrate ingestion in capsules, at least 200 min before exercise, to achieve greater alkalosis, minimize gastrointestinal symptoms, and maximize.
影响因子：
7.1
作者：
Paddon-Jones, Douglas;Westman, Eric;Westerterp-Plantenga, Margriet
通讯作者：
Westerterp-Plantenga, Margriet