Nanoparticle-mediated drug delivery for treating melanoma.
Nanoparticle-mediated drug delivery for treating melanoma.
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DOI：
10.2217/nnm.15.111
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Mahato RI
中科院分区：
文献类型：
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作者：
Mundra V;Li W;Mahato RI
Melanoma originated from melanocytes is the most aggressive type of skin cancer with limited treatment options. New targeted therapeutic options with the discovery of BRAF and MEK inhibitors have shown significant survival benefits. Despite the recent progress, development of chemoresistance and systemic toxicity remains a challenge for treating metastatic melanoma. While the response from the first line of treatment against melanoma using dacarbazine remains only 5–10%, the prolonged use of targeted therapy against mutated oncogene BRAF develops chemoresistance. In this review, we will discuss the nanoparticle-based strategies for encapsulation and conjugation of drugs to the polymer for maximizing their tumor distribution through enhanced permeability and retention effect. We will also highlight photodynamic therapy and design of melanoma-targeted nanoparticles.
