Involvement of the subthalamic nucleus in glutamatergic compensatory mechanisms
Involvement of the subthalamic nucleus in glutamatergic compensatory mechanisms
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DOI：
10.1046/j.1460-9568.1999.00627.x
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发表时间：
1999-06-01
影响因子：
3.4
通讯作者：
Gross, CE
中科院分区：
文献类型：
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作者：
Bézard, E;Boraud, T;Gross, CE
为探讨丘脑底核(STN)是否参与掩盖帕金森病症状前期末期帕金森病患者运动异常的谷氨酸能代偿机制，采用多单位电生理记录方法，采用模拟多巴胺能神经元逐渐死亡的实验方法，观察慢性染毒1-甲基-4-苯基-1，2，3，6-四氢吡啶(MPTP)后，恒河猴丘脑底核(STN)及苍白球外侧部和内侧部的活动变化。STN活性在治疗过程中显著增强，甚至在首次出现临床症状之前(P<；0.01)。这一结果表明，STN甚至在症状前阶段结束之前就增加了它的活动水平，它主要负责刺激谷氨酸能代偿机制，从而维持纹状体多巴胺能动态平衡。
The purpose of the present study was to investigate whether the subthalamic nucleus (STN) was implicated in the glutamatergic compensatory mechanisms which have been shown to mask the parkinsonian motor abnormalities at the end of the presymptomatic period in experimental parkinsonism, Using multiunit electrophysiological recordings, we follow changes of activity occurring in the STN and in both the pars externalis and the pars internalis of the globus pallidus of monkeys chronically intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), according to a protocol designed to mimic the gradual evolution of dopaminergic neuronal death. STN activity augmented significantly in the course of treatment, even before the first appearance of clinical signs (P < 0.01). This result would indicate that the STN, which increases its level of activity even before the end of the presymptomatic period, is principally responsible for the instigation of glutamatergic compensatory mechanisms which allow the maintenance of the striatal dopaminergic homeostasis.