Distinct frontal systems for response inhibition, attentional capture, and error processing
Distinct frontal systems for response inhibition, attentional capture, and error processing
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DOI：
10.1073/pnas.1000175107
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发表时间：
2010-03-30
影响因子：
11.1
通讯作者：
Mehta, M. A.
中科院分区：
文献类型：
--
作者：
Sharp, D. J.;Bonnelle, V.;Mehta, M. A.
响应意外事件而停止操作需要同时关注该事件和禁止该操作。以前的神经影像学研究停止未能充分分离这些认知元素。在这里，我们使用了一个版本的广泛使用的停止信号任务，控制停止信号的注意捕获。这使我们能够对额叶区域（包括右额下回和内侧额叶皮层）在注意捕获、反应抑制和错误处理中的作用进行分形分析。腹侧注意系统，包括右额下回，已经被证明对意外的刺激做出反应。根据这一证据，我们推断，外侧额叶区域支持注意捕获，而内侧额叶区域，包括前补充运动区（pre-SMA），实际上抑制了正在进行的动作。我们通过对比与呈现意外刺激相关的大脑网络和与直接停止相关的大脑网络来验证这一假设。对26名健康志愿者进行了功能磁共振成像。成功停止与右额下回以及前SMA的激活相关。然而，只有前SMA的激活与控制注意力捕获的高水平基线不同。正如预期的那样，不成功的停止尝试激活了前扣带皮层。与在非人灵长类动物中的工作一致，这些发现表明成功的运动抑制与前SMA激活特异性相关。
Stopping an action in response to an unexpected event requires both that the event is attended to, and that the action is inhibited. Previous neuroimaging investigations of stopping have failed to adequately separate these cognitive elements. Here we used a version of the widely used Stop Signal Task that controls for the attentional capture of stop signals. This allowed us to fractionate the contributions of frontal regions, including the right inferior frontal gyrus and medial frontal cortex, to attentional capture, response inhibition, and error processing. A ventral attentional system, including the right inferior frontal gyrus, has been shown to respond to unexpected stimuli. In line with this evidence, we reasoned that lateral frontal regions support attentional capture, whereas medial frontal regions, including the presupplementary motor area (pre-SMA), actually inhibit the ongoing action. We tested this hypothesis by contrasting the brain networks associated with the presentation of unexpected stimuli against those associated with outright stopping. Functional MRI images were obtained in 26 healthy volunteers. Successful stopping was associated with activation of the right inferior frontal gyrus, as well as the pre-SMA. However, only activation of the pre-SMA differentiated stopping from a high-level baseline that controlled for attentional capture. As expected, unsuccessful attempts at stopping activated the anterior cingulate cortex. In keeping with work in nonhuman primates these findings demonstrate that successful motor inhibition is specifically associated with pre-SMA activation.