Glandular function in Sjögren syndrome: assessment with dynamic contrast-enhanced MR imaging and tracer kinetic modeling--initial experience.
Glandular function in Sjögren syndrome: assessment with dynamic contrast-enhanced MR imaging and tracer kinetic modeling--initial experience.
复制标题
干燥综合征的腺体功能：动态对比增强磁共振成像和示踪动力学模型评估——初步经验。
DOI：
10.1148/radiol.2463070298
复制
发表时间：
2008
期刊：
影响因子：
19.7
通讯作者：
V. Rushton
中科院分区：
文献类型：
--
作者：
C. Roberts;G. Parker;C. Rose;Y. Watson;J. O’Connor;S. Stivaros;A. Jackson;V. Rushton
目的
PURPOSE
To prospectively use dynamic contrast material-enhanced magnetic resonance (MR) imaging and a tracer kinetic model to compare parotid gland microvascular characteristics in patients who have Sjögren syndrome (SS) with those in healthy volunteers.
MATERIALS AND METHODS
The local research ethics committee approved the study, and written informed consent was obtained from all participants. Twenty-one patients (19 women, two men; age range, 31-73 years) with a diagnosis of SS and 11 healthy volunteers (10 women, one man; age range, 41-68 years) underwent three-dimensional T1-weighted dynamic contrast-enhanced MR imaging of the parotid gland at 1.5 T. A voxel-wise tracer kinetic model and a model-free analysis were applied to the dynamic MR data. Parameter medians and standard deviations were computed to summarize gland microvascular characteristics and gland heterogeneity, respectively. Differences were investigated by using multivariate analysis of variance, t, or U tests. Further investigation was performed by using linear discriminant and receiver operating characteristic analyses.
RESULTS
Compared with the healthy volunteers, the patients with SS had highly significant elevations (P << .001) in the model-free parameter initial area under the curve and in tracer kinetic model parameters, including transcapillary contrast agent transfer constant (P < .001) and extracellular extravascular volume (P < .001). Gland heterogeneity was significantly greater (P < .001) in the patients with SS. Parameter medians and standard deviations enabled excellent differentiation (areas under receiver operating characteristic curve, 0.96 and 1.00, respectively) between the patients with SS and the healthy volunteers.
CONCLUSION
Dynamic contrast-enhanced MR imaging has the potential to be used in clinical settings to quantify microvascular function in SS and to differentiate between patients with and those without SS.
动态磁共振唾液造影作为干燥综合征患者的一种新诊断技术。
DOI：
--
发表时间：
2006
期刊：
Oral dis. 12(4)
影响因子：
--
作者：
Y;Morimoto.;J;Fukuda.;et al.
通讯作者：
et al.