Antiviral and immunoregulatory effect of a novel exopolysaccharide from a marine thermotolerant Bacillus licheniformis
Antiviral and immunoregulatory effect of a novel exopolysaccharide from a marine thermotolerant Bacillus licheniformis
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DOI：
10.1016/j.intimp.2005.07.004
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发表时间：
2006-01-01
影响因子：
5.6
通讯作者：
Bisignano, G
中科院分区：
文献类型：
--
作者：
Arena, A;Maugeri, TL;Bisignano, G
EPS-1是一种新的胞外多糖，由一株耐热地衣芽孢杆菌产生，分离自意大利Vulcano岛的浅海温泉。本文对EPS-1的抗病毒和免疫调节作用进行了评价。结果发现，EPS-1能抑制人外周血单核细胞（PBMC）中HSV-2的复制，但对WISH细胞无影响。由于多种细胞因子调节对病毒的免疫应答，我们在不同的实验条件下，在PBMC上清液中检测了Th1型和th2型细胞因子。EPS-1可诱导IL-12、ifn - γ、ifn - α、tnf - α和IL-18，但不能诱导IL-4。因此，EPS-1对PBMC的抗病毒作用似乎与细胞因子诱导的模式有关。(c) 2005 Elsevier B.V.版权所有
EPS-1 is a novel extracellular polysaccharide produced by a strain of thermotolerant Bacillus licheniformis, isolated from a shallow marine hot spring of Vulcano Island (Italy). In this paper, antiviral and immunomodulatory effects of EPS-1 were evaluated. It was found that EPS-1 treatment impaired HSV-2 replication in human peripheral blood mononuclear cells (PBMC) but not in WISH cells.Since several cytokines modulate the immune response to viruses, Th1- and Th2-type cytokines were assayed in supernatants of PBMC in different experimental conditions.EPS-1 induced IL-12, IFN-gamma, IFN-alpha, TNF-alpha and IL-18, but not IL-4. Thus, the antiviral effect of EPS-1 on PBMC seems to be related to the pattern of cytokines induced. (c) 2005 Elsevier B.V. All rights reserved.