Inadequate blood supply persists in keloids
Inadequate blood supply persists in keloids
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DOI：
10.1080/02844310410029552
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发表时间：
2004-11-01
影响因子：
--
通讯作者：
Oba, S
中科院分区：
文献类型：
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作者：
Ueda, K;Yasuda, Y;Oba, S
我们以前已经表明，瘢痕疙瘩的三磷酸腺苷（ATP）含量长期保持较高水平。在瘢痕疙瘩中，无氧糖酵解可能与ATP的产生有关。在这项研究中，我们计数血管瘢痕疙瘩，增生性和萎缩性瘢痕在一个定义的区域，并测量其内腔的横截面积免疫组织病理学和乳酸浓度。瘢痕疙瘩中定义区域的平均数量最小，血管的平均内部面积也最小。瘢痕疙瘩的乳酸盐含量为39.4（13.5）mmol/g蛋白质，红色疤痕为23.8（7.5）mmol/g蛋白质，粉红色疤痕为23.8（7.6）mmol/g蛋白质，白色疤痕为13.3（7.3）mmol/g蛋白质。这些结果表明，ATP可能产生的无氧糖酵解瘢痕疙瘩，减少和狭窄的血管可能减少氧灌注。瘢痕疙瘩的血液供应不足，这仍然存在。
We have previously shown that the adenosine triphosphate (ATP) content of keloids remains high for a long time. In keloids, anaerobic glycolysis may be related to the production of ATP. In this study, we counted the vessels in keloids, hypertrophic and atrophic scars in a defined area, and measured the cross-sectional areas of their internal lumens immunohistopathologically and the lactate concentrations. The mean number in a defined area was smallest in keloids as was the mean internal area of vessels. The lactate content of keloids was 39.4 (13.5) mmol/g of protein, of red scars 23.8 (7.5), of pink scars 23.8 (7.6), and of white scars 13.3 (7.3). These results indicate that ATP may be produced by anaerobic glycolysis in keloids, and that the decreased and narrowed vessels may reduce oxygen perfusion. The blood supply to keloids is inadequate, and this persists.