Collecting back-reflected photons in photoacoustic microscopy.
Collecting back-reflected photons in photoacoustic microscopy.
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DOI：
10.1364/oe.18.001278
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发表时间：
2010-01-18
期刊：
影响因子：
3.8
通讯作者：
Puliafito CA
中科院分区：
文献类型：
--
作者：
Zhang HF;Wang J;Wei Q;Liu T;Jiao S;Puliafito CA
Since the photoacoustic effect relies only on the absorbed optical energy, the back-reflected photons from samples in optical-resolution photoacoustic microscopy are usually discarded. By employing a 2 × 2 single-mode fiber optical coupler in a laser-scanning optical-resolution photoacoustic microscope for delivering the illuminating laser light and collecting the back reflected photons, a fiber-optic confocal microscope is integrated with the photoacoustic microscope. Thus, simultaneous multimodal imaging can be achieved with a single light source and images from the two modalities are intrinsically registered. Such capabilities are demonstrated in imaging both phantoms and small animals in vivo.
