Short-term tamoxifen treatment has long-term effects on metabolism in high-fat diet-fed mice with involvement of Nmnat2 in POMC neurons
Short-term tamoxifen treatment has long-term effects on metabolism in high-fat diet-fed mice with involvement of Nmnat2 in POMC neurons
复制标题
短期他莫昔芬治疗对高脂饮食喂养小鼠的代谢具有长期影响，且 POMC 神经元中的 Nmnat2 参与其中
DOI：
10.1002/1873-3468.13240
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发表时间：
2018
期刊：
影响因子：
3.5
通讯作者：
Qiwei Zhai
中科院分区：
文献类型：
--
作者：
Zhiyuan Liu;Yalan Cheng;Yi Luan;Wuling Zhong;Hejin Lai;Hui Wang;Huimin Yu;Yale Yang;Ning Feng;Feixiang Yuan;Rui Huang;Zhishui He;Fang Zhang;Menghong Yan;Hao Yin;Feifan Guo;Qiwei Zhai
短期他莫昔芬治疗对喂食食物的小鼠的脂质和葡萄糖代谢有影响。然而，其对高脂饮食（HFD）小鼠代谢的影响及其潜在机制尚不清楚。在这里，我们表明，他莫昔芬治疗5天减少脂肪质量长达18周的小鼠喂养HFD。他莫昔芬改变白色脂肪组织中参与脂质代谢的一些基因的mRNA水平，并改善葡萄糖和胰岛素耐受性以及肝脏胰岛素信号传导12-20周。烟酰胺单核苷酸腺苷酰转移酶2（Nmnat 2）的前阿黑皮素（POMC）神经元特异性缺失减弱了他莫昔芬对葡萄糖和胰岛素耐受性的影响。这些数据表明，短期注射他莫昔芬对HFD小鼠的脂质和葡萄糖代谢具有长期影响，并涉及POMC神经元中的Nmnat 2。
Short‐term tamoxifen treatment has effects on lipid and glucose metabolism in mice fed chow. However, its effects on metabolism in mice fed high‐fat diet (HFD) and the underlying mechanisms are unclear. Here, we show that tamoxifen treatment for 5 days decreases fat mass for as long as 18 weeks in mice fed HFD. Tamoxifen alters mRNA levels of some genes involved in lipid metabolism in white adipose tissue and improves glucose and insulin tolerance as well as hepatic insulin signaling for 12–20 weeks. Proopiomelanocortin (POMC) neuron‐specific deletion of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) attenuates the effects of tamoxifen on glucose and insulin tolerance. These data demonstrate that short‐term injection of tamoxifen has long‐term effects on lipid and glucose metabolism in HFD mice with involvement of Nmnat2 in POMC neurons.