Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21
Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5' end of the lactase gene on chromosome 2q21
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DOI：
10.1016/s0014-5793(96)01189-1
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发表时间：
1996-12-02
期刊：
影响因子：
3.5
通讯作者：
Swallow, DM
中科院分区：
文献类型：
--
作者：
Harvey, CB;Wang, YX;Swallow, DM
一个酵母细胞分裂周期基因的人类同源基因的四个外显子（MCM 6/mis 5，被认为编码DNA复制许可因子）已被鉴定为在人染色体2 q21上肠乳糖酶基因转录起始上游3.3kb处，最初通过与大鼠“肠隐窝细胞复制因子”的相似性，RT-PCR分析显示，与乳糖酶不同，MCM 6在其组织分布中不受限制，并且在成人肠道中的表达水平中不显示人与人之间的差异。
Four exons of a human homologue of a yeast cell division cycle gene (MCM6/mis5, which is thought to encode a DNA replication licensing factor) have been identified 3.3 kb upstream from the start of transcription of the intestinal lactase gene on human chromosome 2q21, initially by similarity to a rat 'intestinal crypt-cell replication factor', RT-PCR analysis shows, that unlike lactase, MCM6 is not restricted in its tissue distribution and does not show person-to-person variation in the level of expression in adult intestine.