Thalamic projection fiber integrity in de novo Parkinson disease.
Thalamic projection fiber integrity in de novo Parkinson disease.
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DOI：
10.3174/ajnr.a3178
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Vaillancourt DE
中科院分区：
文献类型：
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作者：
Planetta PJ;Schulze ET;Geary EK;Corcos DM;Goldman JG;Little DM;Vaillancourt DE
晚期帕金森病（PD）的死后研究揭示了与疾病相关的病理在丘脑中具有明显的特定丘脑核的偏好。在本研究中，我们使用弥散张量成像（diffusion tensor imaging， DTI）研究了PD患者与健康对照者在体内六个丘脑区域的显微结构完整性。40名受试者（20名早期未经治疗的PD患者和20名年龄和性别匹配的对照组）采用3tesla高分辨率DTI协议进行研究，以研究丘脑核投射纤维的完整性。两名盲法独立评分者在以下六个丘脑区域绘制感兴趣区域（roi）：前核（AN）、腹侧前核（VA）、腹侧外侧核（VL）、背内侧核（DM）、腹侧后外侧核(VPL)/腹侧后内侧核（VPM）和pulvinar （PU）。然后从每个区域的投影纤维计算分数各向异性（FA）值。与对照组相比，PD组AN、VA和DM突出的纤维FA值显著降低，但VPL/VPM和PU没有显著降低。此外，在PD患者的VL中，FA值的降低接近显著性。这些发现在两个评分者中是一致的。本研究提供了新发PD患者丘脑投射纤维变性的初步体内证据，并阐明了该疾病本身导致的丘脑回路中断的程度。
Post-mortem studies of advanced Parkinson’s disease (PD) have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used diffusion tensor imaging (DTI) to investigate in vivo the microstructural integrity of six thalamic regions in de novo PD patients relative to healthy controls. Forty subjects (20 with early-stage, untreated PD and 20 age- and sex-matched controls) were studied with a high-resolution DTI protocol at 3 Tesla to investigate the integrity of thalamic nuclei projection fibers. Two blinded, independent raters drew regions of interest (ROIs) in the following six thalamic regions: anterior nucleus (AN), ventral anterior nucleus (VA), ventral lateral nucleus (VL), dorsomedial nucleus (DM), ventral posterior lateral nucleus (VPL)/ventral posterior medial nucleus (VPM), and pulvinar (PU). Fractional anisotropy (FA) values were then calculated from the projection fibers in each region. FA values were reduced significantly in the fibers projecting from the AN, VA, and DM, but not the VPL/VPM and PU, in the PD group compared to the control group. In addition, there was a reduction in FA values that approached significance in the VL of PD patients. These findings were consistent across both raters. The present study provides preliminary in vivo evidence of thalamic projection fiber degeneration in de novo PD and sheds light on the extent of disrupted thalamic circuitry as a result of the disease itself.