Oxidative stress and erythrocyte acetylcholinesterase (AChE) in hypertensive and ischemic patients of both acute and chronic stages
Oxidative stress and erythrocyte acetylcholinesterase (AChE) in hypertensive and ischemic patients of both acute and chronic stages
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DOI：
10.1016/j.biopha.2007.10.002
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发表时间：
2008-06-01
影响因子：
7.5
通讯作者：
Schetinger, Maria Rosa
中科院分区：
文献类型：
--
作者：
Correa, Maisa de Carvalho;Maldonado, Paula;Schetinger, Maria Rosa
缺血性中风是死亡和残疾的主要原因，尤其是在老年人中。高血压是中风最重要的危险因素，约占所有病例的70%。氧化应激被认为是参与脑卒中神经元损伤的机制之一。胆碱能系统在正常的脑功能和记忆障碍的病理过程中起着重要的作用，如脑血流调节。本研究调查了急性和慢性缺血以及高血压患者全血中的氧化状态和乙酰胆碱酯酶（AChE）活性。与对照组相比，急性缺血组和高血压组的丙二醛（MDA）水平和蛋白质羰基化含量均升高。急性组过氧化氢酶活性和还原型谷胱甘肽（GSH）水平也高于高血压组、慢性缺血组和对照组（P < 0.05）。急性脑缺血组AChE活性显著高于对照组、高血压组和慢性脑缺血组（p < 0.05）。高血压组AChE活性显著低于对照组和慢性组。尽管有一个明确的位置，缺血事件导致全身性疾病，诱导的变化，这可以通过测量氧化应激和AChE活性的外周标志物在红细胞检测。(C)2007年，Elsevier Masson SAS。All rights reserved.
Ischemic stroke is a leading cause of mortality and disability particularly in the elderly. Hypertension is the most important risk factor in strokes, representing roughly 70% of all cases. Oxidative stress is believed to be one of the mechanisms taking part in neuronal damage in stroke. It is well documented that cholinergic system plays a key role in normal brain functions and in memory disturbances of several pathological processes, such as in cerebral blood flow regulation. This study investigated the oxidative status andacetylcholinesterase (AChE) activity in whole blood in patients diagnosed with acute and chronic stages of ischemia, as well as with hypertension. Malondialdehyde (MDA) levels and protein carbonylation content showed increased levels both in the acute ischernic groups and in the hypertensive group, when compared to the control. Catalase activity and reduced glutathione (GSH) levels in the acute group were also higher than in the hypertensive, chronic ischemic and control groups (p < 0.05). The activity of AChE in acute ischemic patients was significantly higher than that presented by the control, hypertensive and chronic ischemic patients (p < 0.05). The hypertensive group presented AChE activity significantly lower than control and chronic groups. In spite of having a defined location the ischernic event results in a systemic disorder that induces changes, which can be detected by measuring the peripheral markers of oxidative stress and AChE activity in erytrocytes. (C) 2007 Elsevier Masson SAS. All rights reserved.