Adherens Junction: Molecular Architecture and Regulation
Adherens Junction: Molecular Architecture and Regulation
复制标题
DOI：
10.1101/cshperspect.a002899
复制
发表时间：
2009-12-01
影响因子：
7.2
通讯作者：
Takeichi, Masatoshi
中科院分区：
文献类型：
--
作者：
Meng, Wenxiang;Takeichi, Masatoshi
粘附体连接（AJ）是细胞-细胞连接的一个元素，钙粘蛋白受体通过它们的亲同性相互作用在邻近的质膜上架起桥梁。钙粘蛋白与称为连环蛋白的细胞质蛋白结合，连环蛋白又与细胞骨架成分结合，如肌动蛋白丝和微管。这些分子复合物进一步与其他蛋白质相互作用，包括信号分子，使AJs成为高度动态和可调节的结构。这种性质的AJs有助于细胞的物理连接，以及细胞间接触的调节，这对组织和器官的形态发生和重塑至关重要。因此，阐明AJs的分子结构及其调控机制对于理解多细胞系统是如何组织的至关重要。
The adherens junction (AJ) is an element of the cell-cell junction in which cadherin receptors bridge the neighboring plasma membranes via their homophilic interactions. Cadherins associate with cytoplasmic proteins, called catenins, which in turn bind to cytoskeletal components, such as actin filaments and microtubules. These molecular complexes further interact with other proteins, including signaling molecules, rendering the AJs into highly dynamic and regulatable structures. The AJs of such nature contribute to the physical linking of cells, as well as to the regulation of cell-cell contacts, which is essential for morphogenesis and remodeling of tissues and organs. Thus, elucidating the molecular architecture of the AJs and their regulatory mechanisms are crucial for understanding how the multicellular system is organized.