Insulin response during the oral glucose tolerance test: The role of age, sex, body fat and the pattern of fat distribution
Insulin response during the oral glucose tolerance test: The role of age, sex, body fat and the pattern of fat distribution
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DOI：
10.1007/bf03340110
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发表时间：
1996-02-01
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影响因子：
--
通讯作者：
Andres, R
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文献类型：
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作者：
Muller, DC;Elahi, D;Andres, R
为了阐明它们在胰岛素对口服葡萄糖反应中的主要作用，应该考虑身体成分的年龄和性别差异。在巴尔的摩老龄化纵向研究中，472名男性和299名女性进行了口服葡萄糖耐量测试，年龄从20岁到96岁不等。正在服用药物或患有任何可能影响葡萄糖耐量的疾病的受试者被排除在外。除了用于葡萄糖耐量试验的胰岛素和葡萄糖值外，我们还计算了体重指数（BMI）、皮肤脂肪百分比（% body fat）、腰臀比（WHR）、2小时试验期间的平均葡萄糖水平（G(M)）、基础胰岛素（I-o）和2小时试验期间的平均胰岛素反应（I-M）。在平均年龄上没有显著的性别差异，但男性的BMI （25.6 vs 24.0 kg/m）、WHR （0.93 vs 0.76）和G(m) （8.5 vs 7.7 mM）明显更高，而% Body Fat （25% vs 33%）较低。男性未调整的I-o和I-M水平明显高于女性（51比44和303比231 pM -对数归一化值的反对数）。然而，通过协方差分析调整了年龄、体脂百分比、WHR和G(M)的差异后，胰岛素水平显示没有性别差异（49 vs 46, 282 vs 257 pM）。调整后的胰岛素水平随着年龄的增长而显著下降；I-M逐渐下降，20 - 39岁为323 pM， 40 - 59岁为267 pM， 60 - 79岁为253 pM， 80 - 96岁为228 pM
To clarify their primary roles on insulin response to oral glucose, age and sex differences in body composition should be taken into account. Oral glucose tolerance rests were performed on 472 men and 299 women of the Baltimore Longitudinal Study of Aging, ranging in age from 20 to 96 years. Subjects who were taking medications or had any diseases which could affect glucose tolerance were excluded. In addition to insulin and glucose values for the glucose tolerance test, we calculated body mass index (BMI), percentage body fat from skinfolds (% Body Fat), waist hip ratio (WHR), mean glucose level over the 2-hour test (G(M)), the basal insulin (I-o), and the mean insulin response over the 2-hour test (I-M). There was no significant sex difference in mean age, but men had significantly higher BMI (25.6 vs 24.0 kg/m(2)), WHR (0.93 vs 0.76), and G(M) (8.5 vs 7.7 mM), while % Body Fat was lower (25% vs 33%). Unadjusted I-o and I-M levels were significantly higher in men than in women (51 vs 44 and 303 vs 231 pM - antilogs of log-normalized values). Insulin levels, adjusted for differences in age, % Body Fat, WHR, and G(M) by analysis of covariance, however, showed no sex differences (49 vs 46 and 282 vs 257 pM). Adjusted insulin levels declined significantly with age; I-M fell progressively from 323 pM in 20 to 39-year olds, 267 pM in 40 to 59-year, 253 pM in 60 to 79-years, and 228 pM in 80 to 96-year olds (p