P104 The role of IPS and TPJ in selective attention in multi-target environments
P104 The role of IPS and TPJ in selective attention in multi-target environments
复制标题
P104 IPS和TPJ在多目标环境中选择性注意中的作用
DOI：
10.1016/j.clinph.2016.10.228
复制
发表时间：
2017
影响因子：
4.7
通讯作者：
de Haan B
中科院分区：
文献类型：
--
作者：
Prass M;de Haan B
同时关注和响应多个目标的能力对于在日常高度动态的多目标环境（如交通场景）中成功导航至关重要。现有文献表明，右侧颞顶交界处（TPJ）和右侧顶内沟（IPS）在同时关注和响应多个目标的能力中发挥着关键作用，然而，这些区域在这种能力中的确切作用目前尚不清楚。在这项研究中，我们将视觉注意力理论 (TVA) 与神经健康受试者的连续 θ 爆发刺激 (cTBS) 结合起来，直接研究正确的 IPS 和 TPJ 在多目标环境中注意力选择中的作用。具体来说，我们研究了暂时抑制右侧 TPJ 或右侧 IPS 神经活动后受损的 TVA 参数，以及这些 TVA 参数与同时关注和响应多个目标的能力的关系。此外，根据最近的研究结果表明，cTBS 对神经元活动的影响在个体之间可能存在很大差异，我们测量了 cTBS 对每个受试者运动皮层运动诱发电位 (MEP) 的影响，以获得 cTBS 后对神经元活动是否存在抑制作用的个体估计。我们的结果表明，对 IPS 进行 cTBS 会导致注意力能力下降，注意力的强度与同时关注和响应多个目标的能力相关。有趣的是，这种效应仅存在于运动皮层 cTBS 对神经元活动产生抑制作用的个体中，如 MEP 减少所示。我们没有发现任何证据表明 TPJ 的 cTBS 调节了任何 TVA 参数。我们的结论是，正确的 IPS 可以通过注意力能力来关键地调节多目标环境中的注意力。此外，我们的结果表明，单独确定 cTBS 对运动皮层神经元活动的影响可能会提供有关 cTBS 后运动皮层以外的皮质区域是否存在抑制作用的有意义的信息。
The ability to attend and respond to multiple targets simultaneously is essential for succesful navigation in everyday highly dynamic multi-target environments like traffic scenes. The existing literature suggests a critical role for both the right temporo-parietal junction (TPJ) and the right intraparietal sulcus (IPS) in the ability to attend and respond to multiple targets simultaneously, however, the precise role of each of these areas in this ability is currently unclear. In this study we combined the Theory of Visual Attention (TVA) with continuous theta burst stimulation (cTBS) in neurologically healthy subjects to directly investigate the role of the right IPS and TPJ in attentional selection in multi-target environments. Specifically, we investigated the TVA parameters impaired after a temporary inhibition of neural activity at either the right TPJ or the right IPS and the relation of these TVA parameters to the ability to attend and respond to multiple targets simultaneously. Additionally, in light of recent findings that suggest that cTBS effects on neuronal activity can be highly variable over individuals, we measured the effect of cTBS to the motor cortex on the motor evoked potential (MEP) in each subject to obtain an individual estimate of the presence or absence of inhibitory effects on neuronal activity following cTBS. Our results suggest that cTBS to the IPS elicited a reduction of attentional capacity, the strength of which correlated with the ability to attend and respond to multiple targets simultaneously. Interestingly, this effect was only present in those individuals in whom cTBS to the motor cortex elicited an inhibitory effect on neuronal activity as indicated by reduced MEPs. We found no evidence that cTBS to the TPJ modulated any of the TVA parameters. We conclude that the right IPS may critically modulate attention in multi-target environments via attentional capacity. Moreover, our results suggest that individually determining the effect of cTBS to the motor cortex on neuronal activity may provide meaningful information concerning the presence or absence of inhibitory effects following cTBS also in cortical areas beyond the motor cortex.