Bioactive glass scaffolds for bone regeneration
Bioactive glass scaffolds for bone regeneration
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DOI：
10.2113/gselements.3.6.393
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发表时间：
2007-12-01
期刊：
影响因子：
4.5
通讯作者：
Polak, Julia
中科院分区：
文献类型：
--
作者：
Jones, Julian R.;Gentleman, Eilen;Polak, Julia
有一个新的材料，可以刺激人体自身的再生机制和愈合组织的需要。多孔模板（支架）被认为是三维组织生长所必需的。本文讨论了骨再生和一个理想的支架规格和材料，可能是合适的。生物活性玻璃作为支架材料具有很高的潜力，因为它们刺激骨细胞产生新骨，它们在体内可降解并与骨结合。综述了两类生物活性玻璃的生物活性机理及其在支架制备中的应用前景。其目前的临床应用的例子突出显示。
There is a need for new materials that can stimulate the body's own regenerative mechanisms and heal tissues. Porous templates (scaffolds) are thought to be required for three-dimensional tissue growth. This article discusses bone regeneration and the specifications of an ideal scaffold and the materials that may be suitable. Bioactive glasses have high potential as scaffold materials as they stimulate bone cells to produce new bone, they are degradable in the body and they bond to bone. The two types of bioactive glasses, their mechanisms for bioactivity and their potential for scaffold production are reviewed. Examples of their current clinical use are highlighted.