Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: Potential for genetic reassortment?
Cocirculation of avian H9N2 and contemporary "human" H3N2 influenza A viruses in pigs in southeastern China: Potential for genetic reassortment?
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DOI：
10.1128/jvi.75.20.9679-9686.2001
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发表时间：
2001-10-01
影响因子：
5.4
通讯作者：
Shortridge, KF
中科院分区：
文献类型：
--
作者：
Peiris, JSM;Guan, Y;Shortridge, KF
猪对人类和禽流感病毒均具有耐受性，并被认为是通过禽病毒重配或适应而产生大流行性流感病毒的中间宿主。 1998年3月至2000年6月期间，在中华人民共和国香港特别行政区对从中国东南部进口的猪进行了前瞻性病毒学监测，首次提供了禽H9N2病毒向猪进行种间传播的证据，并记录了它们与当代人类H3N2（A/Sydney/5/97样、Sydney97样）病毒的共同传播。猪H9N2病毒的所有基因片段与类似鸡/北京/1/94（H9N2）、鸭/香港IY280/97（H9N2）的病毒以及后者病毒谱系的后代密切相关。系统发育分析表明，从禽类宿主到猪，反复发生了种间传播事件。从猪身上分离出来的类悉尼97（H3N2）病毒在所有基因片段上都与当代人类H3N2病毒密切相关，并且没有经历基因重排。禽 H9N2 和人 H3N2 病毒在猪体内的共循环为基因重排提供了机会，从而导致具有大流行潜力的病毒的出现。
Pigs are permissive to both human and avian influenza viruses and have been proposed to be an intermediate host for the genesis of pandemic influenza viruses through reassortment or adaptation of avian viruses. Prospective virological surveillance carried out between March 1998 and June 2000 in Hong Kong, Special Administrative Region, People's Republic of China, on pigs imported from southeastern China, provides the first evidence of interspecies transmission of avian H9N2 viruses to pigs and documents their cocirculation with contemporary human H3N2 (A/Sydney/5/97-like, Sydney97-like) viruses. All gene segments of the porcine H9N2 viruses were closely related to viruses similar to chicken/Beijing/1/94 (H9N2), duck/Hong KongIY280/97 (H9N2), and the descendants of the latter virus lineage. Phylogenetic analysis suggested that repeated interspecies transmission events bad occurred from the avian host to pigs. The Sydney97-like (H3N2) viruses isolated from pigs were related closely to contemporary human H3N2 viruses in all gene segments and had not undergone genetic reassortment. Cocirculation of avian H9N2 and human H3N2 viruses in pigs provides an opportunity for genetic reassortment leading to the emergence of viruses with pandemic potential.