SARS-CoV-2 is transmitted via contact and via the air between ferrets
SARS-CoV-2 is transmitted via contact and via the air between ferrets
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DOI：
10.1038/s41467-020-17367-2
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发表时间：
2020-07-08
影响因子：
16.6
通讯作者：
Herfst, Sander
中科院分区：
文献类型：
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作者：
Richard, Mathilde;Kok, Adinda;Herfst, Sander
SARS-CoV-2是2019年底出现的一种冠状病毒，已在全球范围内迅速传播，有关SARS-CoV-2在人类中传播方式的信息对于采取适当的感染控制措施并减缓其传播至关重要。在这里，我们表明，SARS-CoV-2是有效地通过直接接触和通过空气（通过呼吸道飞沫和/或气溶胶）之间的雪貂，1至3天和3至7天后，分别曝光。直接接触和间接受体雪貂中的病毒脱落模式与接种雪貂的病毒脱落模式相似，并且从所有阳性动物中分离出感染性病毒，表明雪貂通过任一途径被有效感染。这项研究提供了SARS-CoV-2通过空气传播的实验证据，支持实施目前在世界许多国家应用的社区层面的社交距离措施，并为医疗机构感染控制措施的决策提供信息。SARS-CoV-2在全球范围内迅速传播，需要动物模型来研究传播。在这里，Richard等人显示了SARS-CoV-2在雪貂之间通过直接接触和通过空气、通过呼吸道飞沫和/或气溶胶的有效传播。
SARS-CoV-2, a coronavirus that emerged in late 2019, has spread rapidly worldwide, and information about the modes of transmission of SARS-CoV-2 among humans is critical to apply appropriate infection control measures and to slow its spread. Here we show that SARS-CoV-2 is transmitted efficiently via direct contact and via the air (via respiratory droplets and/or aerosols) between ferrets, 1 to 3 days and 3 to 7 days after exposure respectively. The pattern of virus shedding in the direct contact and indirect recipient ferrets is similar to that of the inoculated ferrets and infectious virus is isolated from all positive animals, showing that ferrets are productively infected via either route. This study provides experimental evidence of robust transmission of SARS-CoV-2 via the air, supporting the implementation of community-level social distancing measures currently applied in many countries in the world and informing decisions on infection control measures in healthcare settings. SARS-CoV-2 has rapidly spread globally and animal models to study transmission are needed. Here, Richard et al. show efficient transmission of SARS-CoV-2 between ferrets via direct contact and via the air, through respiratory droplets and/or aerosols.