GABAERGIC MODULATION OF STRIATAL PEPTIDE EXPRESSION IN RATS AND THE ALTERATIONS INDUCED BY DOPAMINE ANTAGONIST TREATMENT
GABAERGIC MODULATION OF STRIATAL PEPTIDE EXPRESSION IN RATS AND THE ALTERATIONS INDUCED BY DOPAMINE ANTAGONIST TREATMENT
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DOI：
10.1016/0304-3940(94)90537-1
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发表时间：
1994-10-24
影响因子：
2.5
通讯作者：
MARSDEN, CD
中科院分区：
文献类型：
--
作者：
JOLKKONEN, J;JENNER, P;MARSDEN, CD
GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhibitor gamma-vinyl GABA there were no significant changes in striatal peptide and GAD67 gene expression. Following repeated administration of the D-2 antagonists, eticlopride and haloperidol, there was an increase in enkephalin and GAD67 mRNA levels and parallel decrease in that of substance P. These were unaffected by co-administration of gamma-vinyl GABA. The D-1 antagonist, SCH 23390 administered alone or together with gamma-vinyl GABA did not alter peptide or GAD67 mRNA levels. It seems that pharmacological stimulation of GABA receptors has little effect on enkephalin, substance P or GAD67 mRNA expression in striatal output neurons.
