Effects of blood viscosity on plasma renin activity and renal hemodynamics.
Effects of blood viscosity on plasma renin activity and renal hemodynamics.
复制标题
血液粘度对血浆肾素活性和肾血流动力学的影响。
DOI：
10.1152/ajprenal.1986.250.1.f40
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Chien,S
中科院分区：
文献类型：
--
作者：
Simchon,S;Chen,RY;Carlin,RD;Fan,FC;Jan,KM;Chien,S
研究了戊巴比妥钠麻醉犬外周血黏度变化对肾脏血流动力学和血浆肾素活性的影响。血液粘度通过红细胞压积的改变（Hct）或血浆粘度的增加（葡聚糖给药）等容性改变。当表观血液粘度因Hct或血浆粘度变化而升高时，动脉血压和肾血流量（RBF）保持相对恒定。因此，血液的高粘度与肾脏血管障碍的减少有关，导致肾脏血流阻力基本不变。肾血管障碍的减少可能是由于肾血管舒张所致。在葡聚糖诱导的高黏度中，PRA的增加与肾血管障碍的降低呈线性相关，相关系数为0.968 （P < 0.005）。当Hct从25%提高到55%时，PRA的增加也与肾血管障碍的降低呈线性相关，相关系数为0.953 （P < 0.005）。这些结果表明，肾血管障碍的减少是对表观血液粘度升高的反应，导致PRA增加。
The effects of alterations in apparent blood viscosity on renal hemodynamics and plasma renin activity (PRA) were studied in dogs anesthetized with sodium pentobarbital. Blood viscosity was altered isovolemically either by changes in hematocrit (Hct) or by an increase in plasma viscosity (dextran administration). Arterial blood pressure and renal blood flow (RBF) remained relatively constant when apparent blood viscosity was elevated by changes in Hct or plasma viscosity. Thus the hyperviscosity of blood was associated with a decrease of renal vascular hindrance, resulting in an essentially unchanged renal flow resistance. The decrease in renal vascular hindrance may result from renal vasodilation. In hyperviscosity induced with dextran, the increase in PRA correlates linearly with the decrease in renal vascular hindrance, with a coefficient of correlation of 0.968 (P less than 0.005). The increase in PRA that resulted when Hct was raised from 25 to 55% also can be correlated linearly with the decrease in renal vascular hindrance, with a coefficient of correlation of 0.953 (P less than 0.005). These results suggest that the decrease in renal vascular hindrance in response to a rise in apparent blood viscosity leads to an increase in PRA.