The exercise-induced expression of BDNF within the hippocampus varies across life-span
The exercise-induced expression of BDNF within the hippocampus varies across life-span
复制标题
DOI：
10.1016/j.neurobiolaging.2004.05.006
复制
发表时间：
2005-04-01
影响因子：
4.2
通讯作者：
Cotman, CW
中科院分区：
文献类型：
--
作者：
Adlard, PA;Perreau, VM;Cotman, CW
自愿运动增加年轻动物海马脑源性神经营养因子（BDNF）的表达在这项研究中，我们研究了在4周的运动中，年轻（2个月），中年晚期（15个月）和老年（24个月）动物海马中BDNF蛋白的诱导。平均跑步距离随着年龄的增长而减少，随着时间的推移，老年动物也保持恒定的活动水平，而其他组则倾向于增加平均跑步距离。所有的动物都表现出BDNF蛋白诱导的双相性，在运动1周后显著增加（P < 0.05），然后在2周时下降到接近久坐的水平。此后，与基线相比，BDNF蛋白水平显著增加（P < 0.05），主要仅在年轻动物中。在整个海马匀浆中，只有特定的BDNF mRNA外显子因运动而发生显著变化（P < 0.05），最大的诱导发生在年轻动物中。因此，BDNF蛋白诱导可能与显著的mRNA变化不直接相关。运动可能是一种治疗涉及BDNF减少的疾病的工具。(C)2004年爱思唯尔公司All rights reserved.
Voluntary exercise increases hippocampal brain-derived neurotrophic factor (BDNF) expression in young animals. In this investigation we examined the induction of BDNF protein in the hippocampus of young (2 months), late middle-aged (15 months) and old (24 months) animals over 4 weeks of exercise. Average running distances decreased with age, with the old animals also maintaining a constant level of activity over time, whereas the other groups tended to increase their average running distance. All animals demonstrated a biphasic profile of BDNF protein induction, with a significant (P < 0.05) increase after 1 week of exercise followed by a decrease to near sedentary levels at 2 weeks. After this, BDNF protein levels increased significantly (P < 0.05), as compared to baseline, primarily only in the young animals. In whole hippocampal homogenates, only particular BDNF mRNA exons were significantly (P < 0.05) changed as a result of exercise, with the largest induction occurring in young animals. BDNF protein induction may, therefore, not be directly correlated with significant mRNA changes. Exercise may represent a therapeutic tool for disorders which involve a decrease in BDNF. (C) 2004 Elsevier Inc. All rights reserved.