Association of steroid 17-alpha-hydroxylase/17,20 lyase (CYP17) single nucleotide polymorphism (SNP) 628 and dopamine receptor D2 (DRD2) SNP939 genotypes with sheep reproductive performance
Association of steroid 17-alpha-hydroxylase/17,20 lyase (CYP17) single nucleotide polymorphism (SNP) 628 and dopamine receptor D2 (DRD2) SNP939 genotypes with sheep reproductive performance
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类固醇 17-α-羟化酶/17,20 裂解酶 (CYP17) 单核苷酸多态性 (SNP) 628 和多巴胺受体 D2 (DRD2) SNP939 基因型与绵羊繁殖性能的关联
DOI：
10.1071/rd18069
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发表时间：
2019
期刊：
影响因子：
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通讯作者：
Yuemin Li
中科院分区：
文献类型：
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作者：
Xiaoyan Qiu;Xiong Xiao;Nan Li;Wenhui Ling;Mingyu Wang;Yuemin Li
在之前的研究中，我们研究了类固醇17- α -羟化酶/17,20裂解酶（CYP17） SNP628和多巴胺受体D2 (DRD2) SNP939两种单核苷酸多态性（SNP）基因型与澳大利亚美利诺羊两种气质（冷静和紧张）之间的关系，得出DRD2 SNP939 T/T基因型与CYP17 SNP628 G/G基因型结合与冷静气质相关的结论，可以作为冷静羊的潜在标记。而DRD2 snp939c等位基因与CYP17 snp628a /A基因型结合的基因型为。与神经质气质有关，可以作为神经质羊的潜在标记。在绵羊中，性情和繁殖性能之间的关系已经确定，但这两种SNP基因型与绵羊繁殖的关系尚未研究。因此，本研究以中国新疆美利奴羊为研究对象，研究了CYP17 SNP628和DRD2 SNP939两种基因型与绵羊繁殖性能的关系。DRD2 SNP939 T/T基因型与CYP17 SNP628 G/G基因型合用的绵羊具有较高的排卵率、多胎率、较好的母性行为和较低的羔羊死亡率。因此，本研究的结果有助于我们了解绵羊基因型与繁殖之间的关系，这对绵羊的遗传和育种有益。
In a previous study we investigated the association between two single nucleotide polymorphism (SNP) genotypes, namely steroid 17-alpha-hydroxylase/17,20 lyase (CYP17) SNP628 and dopamine receptor D2 (DRD2) SNP939, with two temperaments (calm and nervous) in Australian Merino sheep and concluded that the DRD2 SNP939 T/T genotype combined with the CYP17 SNP628 G/G genotype is associated with a calm temperament and could be used as a potential marker for calm sheep, whereas the DRD2 SNP939 C allele combined with the CYP17 SNP628 A/A genotype is.associated with a nervous temperament and could be used as a potential marker for nervous sheep. In sheep, the association between temperament and reproductive performance has been determined, but the association of these two SNP genotypes with sheep reproduction has not been investigated. Therefore, using Chinese Sinkiang Merino sheep, the present study investigated the association of the two CYP17 SNP628 and DRD2 SNP939 genotypes with sheep reproductive performance. Sheep with the DRD2 SNP939 T/T genotype combined with the CYP17 SNP628 G/G genotype had a higher ovulation rate, multiple gestation rate, better maternal behaviour and lower lamb mortality. Thus, the results of this study contribute to our knowledge of the association between genotypes and reproduction in sheep, which is beneficial for sheep genetics and breeding.