Growth and surface folding of esophageal mucosa: a biomechanical model.
Growth and surface folding of esophageal mucosa: a biomechanical model.
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DOI：
10.1016/j.jbiomech.2010.09.007
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发表时间：
2011-01
影响因子：
2.4
通讯作者：
Bo Li;Yan-Ping Cao;Xi-Qiao Feng
中科院分区：
文献类型：
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作者：
Bo Li;Yan-Ping Cao;Xi-Qiao Feng
食道和呼吸道等生物血管中的粘膜折叠对其生理功能是必不可少的，并可受到某些疾病的影响，如炎症、水肿病、淋巴瘤和哮喘。在有限变形理论的框架内，提出了一个生物力学模型来研究由组织中的生长应力和残余应力引起的粘膜折叠。对于生长在圆柱形管腔中的粘膜层，采用超弹性本构关系。对产生的位移场和残余应力场进行了解析求解。此外，不稳定性分析预测了折叠数，这与我们的实验观测结果吻合得很好。这一研究不仅揭示了粘膜折叠的生物力学机制，而且为根据生物组织的折叠特征确定不同生理或病理条件下生物组织的残余应力水平提供了一种很有前途的方法。
Mucosal folding in such biological vessels as esophagus and airway is essential to their physiological functions and can be affected by some diseases, e.g., inflammation, edema, lymphoma, and asthma. A biomechanical model within the framework of finite deformation theory is proposed to address the mucosal folding induced by the growth and residual stresses in the tissue. A hyperelastic constitutive law is adopted for the mucosal layer, which grows in a cylindrical lumen. The fields of the engendered displacements and residual stresses are solved analytically. Furthermore, the instability analysis predicts the folding number, which agrees well with our experimental observations. This study not only sheds light on the biomechanical mechanisms underlying mucosal folding but also provides a promising approach for determining the residual stress level in living tissues under different physiological or pathological conditions according to their folding features.