Regional cerebral glucose metabolism and gait speed in healthy community-dwelling older women.
Regional cerebral glucose metabolism and gait speed in healthy community-dwelling older women.
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DOI：
10.1093/gerona/glu093
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发表时间：
2014-12
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通讯作者：
R. Sakurai;Y. Fujiwara;M. Yasunaga;Rumi Takeuchi;Yoh Murayama;Hiromi Ohba;N. Sakuma;Hiroyuki Suzuki;K. Oda;M. Sakata;J. Toyohara;K. Ishiwata;S. Shinkai;K. Ishii
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文献类型：
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作者：
R. Sakurai;Y. Fujiwara;M. Yasunaga;Rumi Takeuchi;Yoh Murayama;Hiromi Ohba;N. Sakuma;Hiroyuki Suzuki;K. Oda;M. Sakata;J. Toyohara;K. Ishiwata;S. Shinkai;K. Ishii
本研究的目的是探讨身体和精神功能高的老年妇女规范化区域脑葡萄糖代谢率（normalize - rcmrglc）与步态功能之间的关系。方法：182名在社区居住的老年妇女（平均年龄[SD]， 69.4[6.6]岁），无日常生活工具活动障碍，无行动限制，静息时使用18f -氟脱氧葡萄糖进行正电子发射断层扫描，评估与步态功能相关的脑活动。我们测量了16个感兴趣区域的标准化rcmrglc。在使用18f -氟脱氧葡萄糖扫描的正电子发射断层扫描6个月内，在舒适步速和最大步速下测量步态速度、步长和步频作为步态功能指标。规范化rcmrglc与步态指标之间的相关性通过调整人口统计学特征（包括年龄、身高、体重、血压、既往疾病和教育程度）的多元线性回归分析进行检验。结果：即使在个体差异范围内，最大步态速度较慢也与前额叶、后扣带和顶叶皮层的标准化rcmrglc较低相关。最大步速时较低的步频也与这些区域较低的规范化rcmrglc相关。然而，在最大步速下的步长与标准化rcmrglc之间，以及在舒适步速下的所有步态变量与标准化rcmrglc之间，没有显著的关联。结论：特定区域的rcmrglc正常化值与步态功能的个体差异有关，即使在健康的老年妇女中也是如此。大脑的这些区域可能在步态控制中发挥重要作用。了解这些脑区的脑葡萄糖代谢可能有助于早期发现活动受限。
BACKGROUND The objective of this study was to investigate the relationship between normalized regional cerebral metabolic rates of glucose (normalized-rCMRglc) and gait function in physically and mentally high-functioning older women. METHODS One hundred eighty-two community-dwelling older women (mean age [SD], 69.4 [6.6] years) without disability in instrumental activities of daily living and without mobility limitations underwent positron emission tomography with 18F-fluorodeoxyglucose at rest to assess brain activity associated with gait function. We measured normalized-rCMRglc in 16 regions of interest. Within 6 months of the positron emission tomography with 18F-fluorodeoxyglucose scan, gait speed, step length, and step frequency both at comfortable and maximum paces were measured as indices of gait function. Associations between normalized-rCMRglc and gait indices were examined with multiple linear regression analyses adjusted for demographic characteristics, including age, height, body weight, blood pressure, past illness, and education. RESULTS Slower maximum gait speed even in the range of individual difference was associated with lower normalized-rCMRglc in the prefrontal, posterior cingulate, and parietal cortices. Lower step frequency at the maximum pace was also associated with lower normalized-rCMRglc in these regions. However, there was no significant association between step length at the maximum pace and normalized-rCMRglc or between all gait variables at a comfortable pace and normalized-rCMRglc. CONCLUSIONS The normalized-rCMRglc values in specific regions were associated with individual differences in gait function, even in healthy older women. These regions of the cerebrum could play an important role in gait control. Understanding the cerebral glucose metabolism in these brain regions may enable early detection of mobility limitation.